ID B9WFC4_CANDC Unreviewed; 973 AA.
AC B9WFC4;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN OrderedLocusNames=Cd36_40560 {ECO:0000313|CGD:CAL0000161730};
GN ORFNames=CD36_40560 {ECO:0000313|EMBL:CAX41943.1};
OS Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS NRRL Y-17841) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=573826 {ECO:0000313|EMBL:CAX41943.1, ECO:0000313|Proteomes:UP000002605};
RN [1] {ECO:0000313|EMBL:CAX41943.1, ECO:0000313|Proteomes:UP000002605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841
RC {ECO:0000313|Proteomes:UP000002605};
RX PubMed=19745113; DOI=10.1101/gr.097501.109;
RA Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT Candida albicans.";
RL Genome Res. 19:2231-2244(2009).
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DR EMBL; FM992691; CAX41943.1; -; Genomic_DNA.
DR RefSeq; XP_002419728.1; XM_002419683.1.
DR AlphaFoldDB; B9WFC4; -.
DR GeneID; 8047990; -.
DR KEGG; cdu:CD36_40560; -.
DR CGD; CAL0000161730; Cd36_40560.
DR VEuPathDB; FungiDB:CD36_40560; -.
DR eggNOG; KOG0942; Eukaryota.
DR HOGENOM; CLU_002173_2_3_1; -.
DR OrthoDB; 1386at2759; -.
DR Proteomes; UP000002605; Chromosome 4.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:CAX41943.1};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 625..973
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 941
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 973 AA; 113726 MW; B7C3D92D1DF3953A CRC64;
MYNFSGSSKK RVVNLGNKKS GNNNKTNFLE QSRLQRQERE YKKNREKSAI IIQNHIRKYL
DLKRNSFAII NDWLNSHINN EQDFNSWINQ FINLSKWYLL KQDGGLIYQV LESLLDHISD
TMFDIYNTDG MIHALNKLLS CLKDINALYL TVQALYIVAS KTENLGEVNG VIDNLSRLFN
EYQLSREQQS KIFDLIFMIN IHDSHYDFKK ALTLNYFEGE NKKYLQVLRN AIGSTTHALK
FNDDALVRML SSYLIVHGDQ KLTQFDYAFI GSILENIDCE VRLEDDDADD DDFFEKRKFI
NVDKVDPTYP RRIDILYIDE KISNSLEKLY TRSFIQGVIN LLRNETSELR GLALKILPAL
VNLYPALKGK LCMLLSIVPN FYKWVFETIR EHELFHLFIN CNKDYVRTQE LENIDEASMY
SFWKIVFLFE ESYSYWLIVS NDLESFSHEK LPIDDVKLFI GFLKVACLTL IFTYNRTLFP
HYSNLKSIST TLLNQLYLRN LRLKFLPRDY WKLKDLVFNV DLMLSIITEE EESRINAEAD
NEEEIVAVKR SKPVPIEILS KLEVLKTLPF FIEFNHRVEI FQSLIDLDKK RNFSFNPFTF
SESKLVAEIN RDSILEDAFN AYHKEGANFK NRLQVEFFNE YGREAGIDGG GITKEFLTCI
VKEGFNPDNA YELFKETGDN QLYPNDKIFE ILYIGMDKEF QQIKLDYIRF LGMIIGKCLY
ENVLIDVWFA PFFLNKWCND AMKNSINDLS YLDNELFKNL MKLTKMTNDE LKMLELTFSI
NLKIDNKSYT VELLPNGAVI EVDSSNILSY IHQFANYKLN QSLKIQTKYF LEGLYSIISK
SWLSMFDCFE LQMLISGGKD DINIDDWKNN VEYGGYSDSD PAVIMFWEIV EEMSPHERCK
LIKFVTSVSR APLLGFGSLV PKFGIRNSGT DSVRLPTAST CVNLLKLPNY QDKKTMKEKL
LYAINTEARF DLS
//
