ID B9WMC7_CANDC Unreviewed; 707 AA.
AC B9WMC7;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Long-chain-alcohol oxidase {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
DE EC=1.1.3.20 {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
GN OrderedLocusNames=Cd36_32890 {ECO:0000313|CGD:CAL0000167182};
GN ORFNames=CD36_32890 {ECO:0000313|EMBL:CAX40240.1};
OS Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS NRRL Y-17841) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=573826 {ECO:0000313|EMBL:CAX40240.1, ECO:0000313|Proteomes:UP000002605};
RN [1] {ECO:0000313|EMBL:CAX40240.1, ECO:0000313|Proteomes:UP000002605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841
RC {ECO:0000313|Proteomes:UP000002605};
RX PubMed=19745113; DOI=10.1101/gr.097501.109;
RA Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT Candida albicans.";
RL Genome Res. 19:2231-2244(2009).
CC -!- FUNCTION: Long-chain fatty alcohol oxidase involved in the omega-
CC oxidation pathway of lipid degradation.
CC {ECO:0000256|ARBA:ARBA00003842}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain primary fatty alcohol + O2 = a long-chain fatty
CC aldehyde + H2O2; Xref=Rhea:RHEA:22756, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17176, ChEBI:CHEBI:77396; EC=1.1.3.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000920,
CC ECO:0000256|PIRNR:PIRNR028937};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|PIRNR:PIRNR028937}.
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DR EMBL; FM992695; CAX40240.1; -; Genomic_DNA.
DR RefSeq; XP_002422236.1; XM_002422191.1.
DR AlphaFoldDB; B9WMC7; -.
DR SMR; B9WMC7; -.
DR GeneID; 8049385; -.
DR KEGG; cdu:CD36_32890; -.
DR CGD; CAL0000167182; Cd36_32890.
DR VEuPathDB; FungiDB:CD36_32890; -.
DR eggNOG; ENOG502QSD8; Eukaryota.
DR HOGENOM; CLU_008878_3_1_1; -.
DR OrthoDB; 601859at2759; -.
DR UniPathway; UPA00147; -.
DR Proteomes; UP000002605; Chromosome R.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005782; C:peroxisomal matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0047639; F:alcohol oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0046577; F:long-chain-alcohol oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0046188; P:methane catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0015945; P:methanol metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR InterPro; IPR012400; Long_Oxdase.
DR PANTHER; PTHR46056; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR PANTHER; PTHR46056:SF4; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF028937; Lg_Ch_AO; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR028937};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 245..458
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 543..692
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT ACT_SITE 637
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-1"
SQ SEQUENCE 707 AA; 77697 MW; 3DB2001EF7A7119E CRC64;
MVTMDSIFPS KVEYKQVDTF IALCDGLIYD TTVDEIKDVI APDFPQEKLE EYVKTFTRPS
QTPGFREAVY ETVNSNTTNA SRSFGILCNI LGSRILAPTL TNSLTPIKDM TLKEREALLA
SWRDSPLATK RRLFRAVCAL AGTTIVRLAS ELHFKAIHFP QKDLRETAYE GQIIDPFRYE
FMEKPTFEGA EIYLPDIDAI IIGSGAGSGV VAHTLANDGY KTLILEKGKY FSSSELQFDD
YSGVKQLYQG GGAVVTLNQQ MLILAGSTFG GGTTVNWSAC IKTPFKVRKE WYDDFGVEFA
ATDTYDKDQD YVFKQMGAST DGITHSLANE VIMEGGKKLG YASKEINQNS GGHPHHPCGF
CHLGCKYGIK QGSVANWFRD AAANGSKFME QVRVVKILNK NGIAYGVLCQ DVATGVNFTI
TGPKKYVVSA GSLNTPTVLT NSGFKNKHIG RNLTLHPVTT VFGDFGKDVQ ADHFHNSIMT
AVCTQVDDLD GKAHGAKIET ILNAPFLQAA FLPWRGSNEF RRDLLRYNNM VAMLLITRDS
TSGTVKGDPN RPDALYVDYT VNKFDRNALL QALLITADML YIEGAKRILS PQSWVPIFES
NVPKDQRSID DKDYVEWRKK VAGIPFDQYG AAYGSAHQMS SCRMSGKGPA FGAVDTNGKL
FECSNVYVAD ASVLPTASGA NPMISTMTVA RHIGLGLAKD LKTKAKL
//
