ID B9WRU1_CAEEL Unreviewed; 1667 AA.
AC B9WRU1;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=B30.2/SPRY domain-containing protein {ECO:0000313|EMBL:CAX32487.1};
GN Name=hrpu-1 {ECO:0000313|EMBL:CAX32487.1,
GN ECO:0000313|WormBase:Y41E3.11a};
GN ORFNames=CELE_Y41E3.11 {ECO:0000313|EMBL:CAX32487.1}, Y41E3.11
GN {ECO:0000313|WormBase:Y41E3.11a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAX32487.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAX32487.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAX32487.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284604; CAX32487.1; -; Genomic_DNA.
DR RefSeq; NP_001255853.1; NM_001268924.1.
DR AlphaFoldDB; B9WRU1; -.
DR SMR; B9WRU1; -.
DR STRING; 6239.Y41E3.11a.1; -.
DR EPD; B9WRU1; -.
DR PaxDb; 6239-Y41E3-11a; -.
DR PeptideAtlas; B9WRU1; -.
DR EnsemblMetazoa; Y41E3.11a.1; Y41E3.11a.1; WBGene00012769.
DR EnsemblMetazoa; Y41E3.11a.2; Y41E3.11a.2; WBGene00012769.
DR GeneID; 178421; -.
DR KEGG; cel:CELE_Y41E3.11; -.
DR AGR; WB:WBGene00012769; -.
DR WormBase; Y41E3.11a; CE43453; WBGene00012769; hrpu-1.
DR eggNOG; KOG2242; Eukaryota.
DR InParanoid; B9WRU1; -.
DR OMA; HEHWTLI; -.
DR OrthoDB; 5402316at2759; -.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72203; Processing of Capped Intron-Containing Pre-mRNA.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00012769; Expressed in adult organism and 4 other cell types or tissues.
DR ExpressionAtlas; B9WRU1; baseline and differential.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR12381:SF56; B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR12381; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00513; SAP; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 1: Evidence at protein level;
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:B9WRU1,
KW ECO:0007829|PeptideAtlas:B9WRU1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 924..1130
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1360..1427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1482..1563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1638..1667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..117
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..506
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..613
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..659
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..756
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..841
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1387..1424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1644..1667
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1667 AA; 183933 MW; 38726F4B38BB04B7 CRC64;
MRASRRSGAS GTLNKATVPL LPKNRLVKEL QDRGLDTSGV QTVLADRLVE FLSVEDGSIS
SPAVVKKAPA AAKKTPAAKT PKSATKVDSI RRSTRGAQQV KEEEPEEEEE EEEEQDEPVR
ETPKPKRRGR PSIKQEPPEE EAATEDAPVP EVPEVTERRK KQNKENATPL VKKDLKRKAP
AVKIEEPEEP EPGTSQNEPS TSQNGKTTLS TTPQSEERRS RRKSARLLAS EQMDVEDEDE
PEAAADPEPP KIQEPEKKKQ KVSIKEEVPD VAAAVVSQEP QEPPKKQKLT RIKVEVEEED
PDFQPPDESD PIRHSKRIKE HSEHSYDALQ QTQKEKAERA EKLLKKQRTS SSSSQPSPAV
SAQPKPANWQ LEWAAKMAMH KKPAPATTNG VNPEHVKRKE SGEKPAAEVA TKKKKKEAID
TIEALMLSTI KEIVEKKPSI DRPDRPDRPE RPERTVGGSD ASDSSQGFLN KLTSQAAPAP
SPKAQYPTGV FFNQPLPPPP AHPPKIGAHP LVMGGGGGVP MIPMVPMPPG MIGLPPGPPG
RRRKSRFDQP PPEAAAAAQQ FYASTHAPPP TLTTVPQISL RAPPGLASPI PPPPPGRKPL
IDGIPPPPPK PLLATSDLQR RVQEIFSSES SAPAVPVVFS PREASPPPPP PPPRPSALKP
KTEPKQVVLK QEPEEHDDDD DDFVIRDTVV EDEPAPRCRI EQEEASAPPA PVEPLEPLDP
QQEDSAPRAV NKVVEQRKKE ALAEERRRRA MELGDGDGEY NPEDSAIGQD ESEIVWEYQP
IMTRMEDEEE EMEENEGDDE DEDEMVMDDE EEDDDEDEEE ATNLDAPEAP EALEAQEDPE
ELNVLEQNPM ELLKRALPLL HSSTVTEQPK HDYAQLELPI TESLLKRTDD EQPEEVYYHG
DPVPEVDENE LYEIAAGIKP KKKEKKALVQ IPEEERVPAD SETIELDYYN ADILVKSAEK
DIWQIEPFNQ DGLALMWGGI RSNFGIKLPF KQTGKDASHR LAFQIQIDSY QSIQHLPTEF
MADGGDVRIG FSLASTASLI LGESPGSWCI SASGKRAANN HFSDFGKLFD IGDVVTCIFD
LSVGTISYQI NGENVGSPFE SLQFREGDVI FPTICTKNAN INVNMGQELT DEKWKIPEDR
DWMFITEMDR AHLVRSHTAP AAKKDCTVLM TVGLPGVGKT TWVRRYLAEH PHEHWTLISA
DVVMDAMKVN GVPRIRLPTL KRPDFLRGII GKSMNRLILL APRRRKNYIL DMTNCFAEKR
KRKLMAFEEF NRKCMLFVPD EDTHQKRLIK QEHEENEKLD TDAMMQHKAA MSLPIVAEGE
PCEELIFIDP PAGCEQIAFD RVGKMNYDCR SWLVIPGRRR GGGGYNNHHN RGDRGGGGGN
YHHGGYHQYN RPSTSGPPSG GAQYSPRGSS SSTMNITHTT FPSVPSPLVR EEPTIILPPV
KIGLPVVVST ADDSSSPTVA AAVVVAGNNQ FSFPPPPVVM AAPASAAPQT PIQQQQKIQQ
VQQPKKVEVS QPLTLNTSSL PRKSTDSSAG PLSIVSSAGG RSSSFTQQSP RFATTPIPSV
IPPTTTPVQQ IPVMMNISQP PPQIMMSIPP PSMMVQHMRQ PPVVFPIDVT VPPPNFSAPP
PMLPASAGIP PHLLMYHHHQ MSAPPPPTTT PQQAPQFSYP PPQFAPR
//
