ID   B9ZUJ4_CHOCO            Unreviewed;       700 AA.
AC   B9ZUJ4;
DT   14-APR-2009, integrated into UniProtKB/TrEMBL.
DT   14-APR-2009, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Radical SAM methyltransferase {ECO:0000313|EMBL:CAQ43073.1};
GN   Name=cndI {ECO:0000313|EMBL:CAQ43073.1};
GN   ORFNames=CMC5_053230 {ECO:0000313|EMBL:AKT41162.1};
OS   Chondromyces crocatus.
OC   Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae;
OC   Chondromyces.
OX   NCBI_TaxID=52 {ECO:0000313|EMBL:CAQ43073.1};
RN   [1] {ECO:0000313|EMBL:CAQ43073.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Cmc5 {ECO:0000313|EMBL:CAQ43073.1};
RA   Rachid S., Scharfe M., Bloecker H., Weissman K.J., Mueller R.;
RT   "Novel chemistry in the biosynthesis of the antibiotic chondrochlorens.";
RL   Chem. Biol. 16:70-81(2009).
RN   [2] {ECO:0000313|EMBL:AKT41162.1, ECO:0000313|Proteomes:UP000067626}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Cm c5 {ECO:0000313|EMBL:AKT41162.1,
RC   ECO:0000313|Proteomes:UP000067626};
RA   Zaburannyi N., Bunk B., Maier J., Overmann J., Mueller R.;
RT   "Genome analysis of myxobacterium Chondromyces crocatus Cm c5 reveals a
RT   high potential for natural compound synthesis and the genetic basis for the
RT   loss of fruiting body formation.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR   EMBL; CP012159; AKT41162.1; -; Genomic_DNA.
DR   EMBL; AM988861; CAQ43073.1; -; Genomic_DNA.
DR   RefSeq; WP_050432977.1; NZ_CP012159.1.
DR   AlphaFoldDB; B9ZUJ4; -.
DR   STRING; 52.CMC5_053230; -.
DR   KEGG; ccro:CMC5_053230; -.
DR   OrthoDB; 9762608at2; -.
DR   BioCyc; MetaCyc:MONOMER-19497; -.
DR   Proteomes; UP000067626; Chromosome.
DR   GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR   Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR   InterPro; IPR040081; CndI-like.
DR   InterPro; IPR006158; Cobalamin-bd.
DR   InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR   PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDF00423; chondrochloren_A_methyltransfe; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SMART; SM00729; Elp3; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51332; B12_BINDING; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:CAQ43073.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000067626};
KW   Transferase {ECO:0000313|EMBL:CAQ43073.1}.
FT   DOMAIN          74..208
FT                   /note="B12-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51332"
FT   DOMAIN          254..474
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
FT   REGION          671..700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   700 AA;  78058 MW;  E5110FF1C2CD4143 CRC64;
     MATDILVIVP VEPPIAHFAD SVVRQTSGGR LHMPLTQAFH EFEEYVGAAL ELYKPSQRPH
     FGGEMWPPVI GTKAADFLAS RAAQPPRRTL ASITLATHLE RAGLRWEVVD PGMQELHYWR
     KRFEQARANN PTAIAICTTF IVCEPWLRAL CHVIREVLPS TKIIMGGYYY AVNVKKFLAL
     DADIFCVGEG EQRLPAIVQA LKGQRSLEEI PGLYIRRPDG GTHHTGSVEQ LDMNELPIVD
     WSLSTRVEPP IDPIATPVAT WVETQRGCVF SCEFCDYRTI QTPAVMTTDR AAEAILAAGV
     SPRGSVRITD STATFPHKRW EEVLQKLIER GGSKAPLWCF ARVSDINERS AELMKLAGVQ
     HMFIGQESGD QRVLTEMKKG TNVKQVRPAV AALAKHGLNA TFAFIHGFPG EDDASIQATR
     TLIKTLNDGH EDRPVALLYL AQPLVLFDLA TVSQRPEMQG VDHWMAYDNA RFPPQRALAE
     VLQTVMEVSR IPHAPAYLLM PGTFPGYWEE YFFFSPHRYE VFRWMKALER GVAIFLERDL
     EGTKPNDAEL ARLKEQILAR REAIPVWRSR AERMAARAQR LVVQRLTREW TNEGKTGPGP
     LTRGLMGLSV LRDTRNPQLA REALKTGVYP TLGTVNLKES ELDSLAADLR DESLGVEHRR
     RQVAAARKAF VPASALSRRG PNGEPVTPGA SDPAENDAAT
//