ID BRLF1_SHV21 Reviewed; 535 AA.
AC Q01012;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=Putative transcription activator BRLF1 homolog;
DE AltName: Full=Transcription activator EDRF1;
GN Name=50; Synonyms=EDRF1;
OS Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Gammaherpesvirinae; Rhadinovirus;
OC Rhadinovirus saimiriinegamma2; Saimiriine herpesvirus 2.
OX NCBI_TaxID=10383;
OH NCBI_TaxID=9521; Saimiri sciureus (Common squirrel monkey).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=1321287; DOI=10.1128/jvi.66.8.5047-5058.1992;
RA Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B.,
RA Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B.,
RA Honess R.W.;
RT "Primary structure of the herpesvirus saimiri genome.";
RL J. Virol. 66:5047-5058(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1314457; DOI=10.1016/0042-6822(92)90759-i;
RA Nicholas J., Cameron K.R., Coleman H., Newman C., Honess R.W.;
RT "Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus
RT saimiri (HVS) L-DNA: general conservation of genetic organization between
RT HVS and Epstein-Barr virus.";
RL Virology 188:296-310(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RA Nicholas J., Coles L.S., Newman C., Honess R.W.;
RT "Regulation of the herpesvirus saimiri (HVS) delayed-early 110-kilodalton
RT promoter by HVS immediate-early gene products and a homolog of the Epstein-
RT Barr virus R trans activator.";
RL J. Virol. 62:2457-2466(1988).
CC -!- FUNCTION: Transcription activation. Regulates the delayed-early 110 kDa
CC promoter.
CC -!- SIMILARITY: Belongs to the herpesviridae TAF50 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA46124.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAA46159.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA45672.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X64346; CAA45672.1; ALT_INIT; Genomic_DNA.
DR EMBL; M86409; AAA46124.1; ALT_INIT; Genomic_DNA.
DR EMBL; M60850; AAA46159.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_040252.1; NC_001350.1.
DR GeneID; 1682466; -.
DR KEGG; vg:1682466; -.
DR Proteomes; UP000000587; Segment.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR004998; Herpes_TAF50.
DR Pfam; PF03326; Herpes_TAF50; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Early protein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..535
FT /note="Putative transcription activator BRLF1 homolog"
FT /id="PRO_0000116203"
FT REGION 384..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 60051 MW; B4F2B9ABA38816FB CRC64;
MQRIPLWLVR STHCLILLFQ DDVQVRKSCL EPFLFLSPER KREIHQLLVA FNQSLVTPTQ
DEEKILSDIQ RACLQIAEDL KHLNPFTGLL LDLNLYTLWT LLRNYKTKQR SQPVNSTVVS
RYAHHVVKYI MQRLVYTTDR LFLTAPTSGI VLPVPLANAI FNLLSHCRKK CTGLWRNYGT
EKSVLMGLGK EITLCYQALN ESGIVSTTLA AFIKLSFPTI SIPNLFKPMF QSCKGNQDNF
PDICTQGSVI RRPHQGVFGD TFPIPDPLMR EISENSFKKF STANISTLLQ NPKEILEMDP
FDPRIGGFPL NKEETATPLK DSSFSNPTFI NTGAANTLLP AASVTPALES LFSPTHFPCM
SDESIASTSH VPLDNNISLP TLVKTNFPLK RKRQSRNIDP NTPRRPRGRP KGSKTKKRPT
CSPALFQSSD IPTDSLHVKC PEMLPTVPQN EFCDSSNIQP CTSSSVLEND NLVPINEAET
DDNILATILQ DLYDLPAPPV LCSHENQTLE IDNNVDIEDL GLSFPMSLQD FLNDE
//
