ID BRNP2_MOUSE Reviewed; 783 AA.
AC Q6DFY8; Q80T96;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE RecName: Full=BMP/retinoic acid-inducible neural-specific protein 2;
DE Flags: Precursor;
GN Name=Brinp2; Synonyms=Fam5b, Kiaa1747;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=20025061; DOI=10.1002/jnr.22315;
RA Terashima M., Kobayashi M., Motomiya M., Inoue N., Yoshida T., Okano H.,
RA Iwasaki N., Minami A., Matsuoka I.;
RT "Analysis of the expression and function of BRINP family genes during
RT neuronal differentiation in mouse embryonic stem cell-derived neural stem
RT cells.";
RL J. Neurosci. Res. 88:1387-1393(2010).
CC -!- FUNCTION: Inhibits neuronal cell proliferation by negative regulation
CC of the cell cycle transition. {ECO:0000269|PubMed:20025061}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Weakly expressed in embryonic stem (ES) cells.
CC Strongly expressed in ES-derived neural stem cells (NSCs).
CC {ECO:0000269|PubMed:20025061}.
CC -!- INDUCTION: Up-regulated upon differentiation into neuronal cells in the
CC presence of retinoic acid and BDNF. Down-regulated upon differentiation
CC into astroglial cells. {ECO:0000269|PubMed:20025061}.
CC -!- SIMILARITY: Belongs to the BRINP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC65831.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK122549; BAC65831.1; ALT_INIT; mRNA.
DR EMBL; BC076572; AAH76572.1; -; mRNA.
DR CCDS; CCDS15401.1; -.
DR RefSeq; NP_997466.2; NM_207583.2.
DR RefSeq; XP_006496899.1; XM_006496836.1.
DR RefSeq; XP_006496900.1; XM_006496837.1.
DR AlphaFoldDB; Q6DFY8; -.
DR STRING; 10090.ENSMUSP00000004133; -.
DR GlyConnect; 2158; 2 N-Linked glycans (1 site).
DR GlyCosmos; Q6DFY8; 6 sites, 2 glycans.
DR GlyGen; Q6DFY8; 7 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site).
DR iPTMnet; Q6DFY8; -.
DR PhosphoSitePlus; Q6DFY8; -.
DR jPOST; Q6DFY8; -.
DR MaxQB; Q6DFY8; -.
DR PaxDb; 10090-ENSMUSP00000004133; -.
DR PeptideAtlas; Q6DFY8; -.
DR ProteomicsDB; 265234; -.
DR Antibodypedia; 55637; 51 antibodies from 10 providers.
DR DNASU; 240843; -.
DR Ensembl; ENSMUST00000004133.11; ENSMUSP00000004133.9; ENSMUSG00000004031.14.
DR GeneID; 240843; -.
DR KEGG; mmu:240843; -.
DR UCSC; uc007ddp.2; mouse.
DR AGR; MGI:2443333; -.
DR CTD; 57795; -.
DR MGI; MGI:2443333; Brinp2.
DR VEuPathDB; HostDB:ENSMUSG00000004031; -.
DR eggNOG; ENOG502QQZS; Eukaryota.
DR GeneTree; ENSGT00940000160314; -.
DR HOGENOM; CLU_018347_0_0_1; -.
DR InParanoid; Q6DFY8; -.
DR OMA; LSACCRW; -.
DR OrthoDB; 3949486at2759; -.
DR PhylomeDB; Q6DFY8; -.
DR TreeFam; TF331600; -.
DR BioGRID-ORCS; 240843; 2 hits in 78 CRISPR screens.
DR ChiTaRS; Brinp2; mouse.
DR PRO; PR:Q6DFY8; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q6DFY8; Protein.
DR Bgee; ENSMUSG00000004031; Expressed in primary visual cortex and 70 other cell types or tissues.
DR ExpressionAtlas; Q6DFY8; baseline and differential.
DR Genevisible; Q6DFY8; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0071300; P:cellular response to retinoic acid; IDA:UniProtKB.
DR GO; GO:0021953; P:central nervous system neuron differentiation; IDA:UniProtKB.
DR GO; GO:0045786; P:negative regulation of cell cycle; ISO:MGI.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IDA:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:InterPro.
DR InterPro; IPR033237; BRINP.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR15564:SF8; BMP_RETINOIC ACID-INDUCIBLE NEURAL-SPECIFIC PROTEIN 2; 1.
DR PANTHER; PTHR15564; MACPF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF19052; BRINP; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Glycoprotein; Growth arrest; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..783
FT /note="BMP/retinoic acid-inducible neural-specific protein
FT 2"
FT /id="PRO_0000045771"
FT DOMAIN 85..281
FT /note="MACPF"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 354
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 473
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 579
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 626
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 658
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 183
FT /note="T -> P (in Ref. 1; BAC65831)"
FT /evidence="ECO:0000305"
FT CONFLICT 620
FT /note="A -> T (in Ref. 1; BAC65831)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 783 AA; 89228 MW; CD78821BF51A5B6E CRC64;
MRWPCSSWFR GLWPEAAPWA VLLALGVPGW VLAVSATVAA VVPEQHVSSA GQAPLDWLLT
DRGPFHRAQE YADFMERYRQ GFTTRYRIYR EFARWKVNNL ALERRDFFSL PLPLAPEFVR
NIRLLGRRPN LQQVTENLIK KYGTHFLLSA TLGGEESLTI FVDKRKLSRK SETTGGIPVV
GGTGNSSAVS LETLHQLAAS YFIDRESTLR RLHHIQIATG AIKVTETRTG PLGCSNYDNL
DSVSSVLVQS PENKVQLLGL QVLLPEHLRE RFVAAALSYI TCSSEGELVC RENDCWCKCS
PTFPECNCPD ADIQAMEDSL LQIQDSWATH NRQFEESEEF QTLLKRLPSD RFLNSTAISQ
YWTMDSNLQH RYQQLGASLK VLLKKMHRIV RRLFNLCKRC HRQPRFRLPK ERSLSFWWNR
IQSLLYCGES TFPGTFLEQS HSCTCPYDQS SCQGPIPCAL GEGPACAHCA SDNSTRCGSC
NPGYVLAQGL CRPEVAESLE NFLGLETDLQ DLELKYLLQK RDSRIEVHSI FISNDMRLGS
WFDPSWRKRM LLTLKSNKYK PGLVHVMLAL SLQICLTKNS TLEPVMAIYV NPFGGSHSES
WFMPVNEGNF PDWERTNVDA AAQCQNWTIT LGNRWKTFFE TVHVYLRSRI KSLDDSSNET
IYYEPLEMTD PSKNLGYMKI NTLQVFGYSL PFDPDAIRDL ILQLDYPYTQ GSQDSALLQL
IELRDRVNQL SPPGKVRLDL FSCLLRHRLK LANNEVGRIQ SSLRAFNSKL PNPVEYETGK
LCS
//
