ID C0E822_9CORY Unreviewed; 295 AA.
AC C0E822;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Oxidoreductase, aldo/keto reductase family protein {ECO:0000313|EMBL:EEG25547.1};
GN ORFNames=CORMATOL_03164 {ECO:0000313|EMBL:EEG25547.1};
OS Corynebacterium matruchotii ATCC 33806.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=566549 {ECO:0000313|EMBL:EEG25547.1, ECO:0000313|Proteomes:UP000006247};
RN [1] {ECO:0000313|EMBL:EEG25547.1, ECO:0000313|Proteomes:UP000006247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33806 {ECO:0000313|EMBL:EEG25547.1,
RC ECO:0000313|Proteomes:UP000006247};
RA Fulton L., Clifton S., Chinwalla A.T., Mitreva M., Sodergren E.,
RA Weinstock G., Clifton S., Dooling D.J., Fulton B., Minx P., Pepin K.H.,
RA Johnson M., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEG25547.1}.
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DR EMBL; ACEB01000053; EEG25547.1; -; Genomic_DNA.
DR RefSeq; WP_005523809.1; NZ_EQ973332.1.
DR AlphaFoldDB; C0E822; -.
DR HOGENOM; CLU_023205_0_1_11; -.
DR Proteomes; UP000006247; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19071; AKR_AKR1-5-like; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857}.
FT DOMAIN 20..267
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT REGION 265..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 53
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 115
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 82
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 295 AA; 32323 MW; 2DAED5D88E66FC1E CRC64;
MSEKYVPTFT LNDGVEVPAV GLGTWQMQGD EVITAVRSAI DTGYRHIDTA AFYQNEADIG
RAIHDAISAG DVTREELFIT SKVWNDQQSD HEVQAAFRAS LTNLGLDYLD CYMVHWPCPS
TGRHVERFAA LSTLQGLGDV RSIAVANYNG DQLREVQEKT GIVPTINQVE LHPGFSQAEL
RETHAQLGVL TEAWSPLAQG DVNHTGLLVD IADKYGVTPA QVALRWIYQL GASSVPKSAT
ATRQEENIEI FNFELSESEM SRILQLDDGP GSGRRYADPD VFPGDDVGGT PTTQK
//
