ID   C0FR90_9FIRM            Unreviewed;       571 AA.
AC   C0FR90;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   SubName: Full=Penicillin-binding protein, transpeptidase domain protein {ECO:0000313|EMBL:EEG94952.1};
GN   ORFNames=ROSEINA2194_01244 {ECO:0000313|EMBL:EEG94952.1};
OS   Roseburia inulinivorans DSM 16841.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=622312 {ECO:0000313|EMBL:EEG94952.1, ECO:0000313|Proteomes:UP000003561};
RN   [1] {ECO:0000313|EMBL:EEG94952.1, ECO:0000313|Proteomes:UP000003561}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16841 {ECO:0000313|EMBL:EEG94952.1,
RC   ECO:0000313|Proteomes:UP000003561};
RA   Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA   Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEG94952.1, ECO:0000313|Proteomes:UP000003561}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16841 {ECO:0000313|EMBL:EEG94952.1,
RC   ECO:0000313|Proteomes:UP000003561};
RA   Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA   Gordon J.;
RT   "Draft genome sequence of Roseburia inulinivorans (DSM 16841).";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEG94952.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ACFY01000052; EEG94952.1; -; Genomic_DNA.
DR   RefSeq; WP_007884315.1; NZ_JAJFOJ010000002.1.
DR   AlphaFoldDB; C0FR90; -.
DR   GeneID; 75164328; -.
DR   eggNOG; COG0768; Bacteria.
DR   Proteomes; UP000003561; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          55..201
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          244..563
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   571 AA;  63042 MW;  E253DC97648354E2 CRC64;
     MYRNKTFNRK KVMIVFVAVF FIMMFLIGRL VYLMIFCSEY YGNKAENLHE RERDIKAARG
     KLLDANGTVL ATNKSVCTIS VIHNQIEEPE KVIEMLVREL GIPEETARKR VEKVSSIERV
     KTNVAKETGD AIRAYGLSGV KVDEDYKRYY PYGTLASKVL GFTGADNQGI LGLEVKYDEY
     LQGTNGKILT LTDARGIEIE NAGESRLEPV NGYDLCLSLD YNIQMYCEQA AKKVCTKKSA
     DSVSVIVMNP QNGELMAMVN YPEFDLNNPF TLAGDTGEAV SAEEKQNLLN KMWRNQCISD
     TYEPGSTFKI ITAAAALEEG VVKLDDAFFC PGYKIVEDRR IRCARTTGHG AETFETGIMN
     SCNPVFMELG ERLGAENFVG YFKQFGLLSK TNIDLPGEAG TIMHKTENIG PVELATISFG
     QSFQITPIQL VTTVSSIING GTRVTPHFGV SVQDADGNTA KTFSDETHEN ICTAETSETM
     RYLLEKVVSE GTGKNAKIEG FSIGGKTATS QTLPRSDHKY ISSFLGFAPA DNPQVLVLVV
     INNPQGIYYG GTIAAPVAKE IFENILPYLD K
//