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Database: UniProt
Entry: C0FUY0_9FIRM
LinkDB: C0FUY0_9FIRM
Original site: C0FUY0_9FIRM 
ID   C0FUY0_9FIRM            Unreviewed;       606 AA.
AC   C0FUY0;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   SubName: Full=Thiamine pyrophosphate enzyme, central domain protein {ECO:0000313|EMBL:EEG93584.1};
GN   ORFNames=ROSEINA2194_02551 {ECO:0000313|EMBL:EEG93584.1};
OS   Roseburia inulinivorans DSM 16841.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=622312 {ECO:0000313|EMBL:EEG93584.1, ECO:0000313|Proteomes:UP000003561};
RN   [1] {ECO:0000313|EMBL:EEG93584.1, ECO:0000313|Proteomes:UP000003561}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16841 {ECO:0000313|EMBL:EEG93584.1,
RC   ECO:0000313|Proteomes:UP000003561};
RA   Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA   Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEG93584.1, ECO:0000313|Proteomes:UP000003561}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16841 {ECO:0000313|EMBL:EEG93584.1,
RC   ECO:0000313|Proteomes:UP000003561};
RA   Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA   Gordon J.;
RT   "Draft genome sequence of Roseburia inulinivorans (DSM 16841).";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEG93584.1}.
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DR   EMBL; ACFY01000096; EEG93584.1; -; Genomic_DNA.
DR   RefSeq; WP_007886863.1; NZ_JAJFOJ010000001.1.
DR   AlphaFoldDB; C0FUY0; -.
DR   GeneID; 75161070; -.
DR   eggNOG; COG0028; Bacteria.
DR   Proteomes; UP000003561; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd00568; TPP_enzymes; 1.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR18968:SF142; ACETOLACTATE SYNTHASE; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          4..108
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          204..340
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          405..553
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   606 AA;  66768 MW;  A9748C1566A07DF7 CRC64;
     MKIKVAKFIS QFLVDNGITD CFMVTGGGAM HLDDAIGHQE GMHCVFNHHE QACSIAAEGY
     TRMTGKLAAV CVTSGPGGTN AITGVMGGWL DSIPMFVISG QVKRETTTWS CQELGLRQLG
     DQEFDIINSV SNMTKYAVML TNPKEVAYHM EKALYLALNG RGGPVWIDVP LDVQGAMIET
     EELIHFNPAE EKPWQVPEVK LEVVDTILEK IKKAKAPLIL VGTGIRLGGA EELLLKLLDK
     LQIPVVTAWN ANDVLAADSP YFAGMPGTVG TRPGNFAIQN CDLLLSLGCR LNIRMIGYNH
     YDFAKNAYKI IVDIDPRELV KPTIRPDMPV NADVKDLISK MLDSDYNAET KHKKWLVWCQ
     NLMKEYPAAC KEYHRNDGGV INPYIFMDKL FDHLNNNDRI ICGNGSACVI TFQAGKIKQG
     QRMFTNSGCA AMGYGLPAAL GVAVSDNSRR TICIDGDGSI MMNVQELATI VQNNLDIKII
     LLNNNGYHSI RQTQTNLFQP PFIGIDEKSG VGFPDFKVLA QAFGMKYYVL DNEENCSQVL
     EEALNCEGAC ICEAIVDPSQ NFAPKSSSKV LPDGRITSPS LDDMAPFLDR EEFEKIKSEA
     TMIKEE
//
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