ID C0H5G8_PLAF7 Unreviewed; 841 AA.
AC C0H5G8;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE SubName: Full=Aminomethyltransferase, putative {ECO:0000313|EMBL:CAX64346.1};
DE EC=2.1.2.10 {ECO:0000313|EMBL:CAX64346.1};
GN ORFNames=PF3D7_1344000 {ECO:0000313|EMBL:CAX64346.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64346.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR EMBL; AL844509; CAX64346.1; -; Genomic_DNA.
DR RefSeq; XP_002809065.1; XM_002809019.1.
DR AlphaFoldDB; C0H5G8; -.
DR SMR; C0H5G8; -.
DR STRING; 36329.C0H5G8; -.
DR PaxDb; 5833-MAL13P1-390; -.
DR EnsemblProtists; CAX64346; CAX64346; PF3D7_1344000.
DR GeneID; 9221986; -.
DR KEGG; pfa:PF3D7_1344000; -.
DR VEuPathDB; PlasmoDB:PF3D7_1344000; -.
DR HOGENOM; CLU_335417_0_0_1; -.
DR InParanoid; C0H5G8; -.
DR OMA; NIPYMSF; -.
DR OrthoDB; 5473523at2759; -.
DR PhylomeDB; C0H5G8; -.
DR Proteomes; UP000001450; Chromosome 13.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004047; F:aminomethyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01571; GCV_T; 2.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Transferase {ECO:0000313|EMBL:CAX64346.1}.
FT DOMAIN 399..551
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 638..712
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 761..802
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
FT REGION 228..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 98779 MW; 7090BB40531B5EA8 CRC64;
MQKYISYFAN EFCHYKIKDG SSLFLQFSFP SFLDELFIQK SNRKFGTYGA VTRRRQELRQ
KFYEEKYKHN PNNIPKYSKV KKGSRGGWIK NPLKEVTKNC GNNFKYEEKI KEEILSEEEE
CIKNMIKMRK ELMNKSNIDK DYNELINNDS KNINISNNIL NFNLFSICDN FIDKKKEIIH
KIESPQHFVD KHIKTLVDTY SNINELHENY NANNNYPKTP DYLKDIHDKK KKKKKQTNQK
NGSGKEIENN FINVKMEHNC IMDKNEKEKE DNLKCHNEEG SNVLIDNMLI NSNNNTNVGN
PLFNSFIKTD ELYKQHVIPL PLEEKGKNDE NHVIEKFECD PNNDNLKNLY MNEHDWKKLY
IEDLLNYTDE NDIDIGCLDI FSTLNTIDRN RKLGSYFSKN NASFILYNNC IIPSKYKDGT
LNEYLHTRNK CSLFDKSYQL IIKLSGNDCF YICNQFISSD IYDVNNYDAF YTCIIDNKAY
ILDTCYVLKA EKDITLITSG YYKKGLYEFL SDYILFCKDS GMDVHIQVDI NKRILSLQGP
LSNMIFNDIL EYYDWNNKDK SIGYLNNVII KKHNNKNDQK KICTDVNTLY FKSDDHNPIK
SSYFQIPYMS FKKFNVIKNG AILNDNKQNI NKSLDIYEII CIRIGDTGED GYEFIVDNNI
SNLFVDIFLN HKIVKLAGAY ALDILRMESG FPLYGTDIIK NTSPITASLA WTLKYKKIKE
KSIFGFQNLL KEYSMKPKFL RVGILSNQLI FKTCKILSYP YKRPIGYITS CTWSPIYKKR
IAQGYIKRDF AKNNEQVLIS IPTDIPQDFS KKKKYKILRS RSAHKFTLAQ VCALPFVEHK
Y
//