ID C0HEK6_MAIZE Unreviewed; 280 AA.
AC C0HEK6;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Ubiquitin thioesterase OTU {ECO:0000256|RuleBase:RU367104};
DE EC=3.4.19.12 {ECO:0000256|RuleBase:RU367104};
GN Name=100284472 {ECO:0000313|EnsemblPlants:Zm00001eb034890_P005};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:ACN25459.1};
RN [1] {ECO:0000313|EMBL:ACN25459.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B73 {ECO:0000313|EMBL:ACN25459.1};
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
RN [2] {ECO:0000313|EnsemblPlants:Zm00001eb034890_P005, ECO:0000313|Proteomes:UP000007305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb034890_P005,
RC ECO:0000313|Proteomes:UP000007305};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:Zm00001eb034890_P005}
RP IDENTIFICATION.
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb034890_P005};
RG EnsemblPlants;
RL Submitted (MAY-2021) to UniProtKB.
CC -!- FUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins
CC and may therefore play an important regulatory role at the level of
CC protein turnover by preventing degradation.
CC {ECO:0000256|RuleBase:RU367104}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|RuleBase:RU367104};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367104}.
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DR EMBL; BT060762; ACN25459.1; -; mRNA.
DR AlphaFoldDB; C0HEK6; -.
DR EnsemblPlants; Zm00001eb034890_T005; Zm00001eb034890_P005; Zm00001eb034890.
DR Gramene; Zm00001eb034890_T005; Zm00001eb034890_P005; Zm00001eb034890.
DR Proteomes; UP000007305; Chromosome 1.
DR ExpressionAtlas; C0HEK6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-UniRule.
DR CDD; cd22760; OTU_plant_OTU4-like; 1.
DR Gene3D; 3.90.70.80; -; 1.
DR InterPro; IPR047947; OTU4_OTU.
DR InterPro; IPR003323; OTU_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR PANTHER; PTHR13312; HIV-INDUCED PROTEIN-7-LIKE PROTEASE; 1.
DR PANTHER; PTHR13312:SF4; OTU DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02338; OTU; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50802; OTU; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|RuleBase:RU367104};
KW Hydrolase {ECO:0000256|RuleBase:RU367104};
KW Protease {ECO:0000256|RuleBase:RU367104};
KW Proteomics identification {ECO:0007829|PeptideAtlas:C0HEK6};
KW Reference proteome {ECO:0000313|Proteomes:UP000007305};
KW Thiol protease {ECO:0000256|RuleBase:RU367104};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU367104}.
FT DOMAIN 133..271
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
SQ SEQUENCE 280 AA; 30972 MW; E197C00CF16CFB6C CRC64;
MASWKCSHSP SSPYLAKSGL VDSSLNRNVK SSQPQSIKYF VSLMGQQFRC GLSTREGSLS
VKLDIPSHEK SRIGWNWKNM HQKIGGVAGG LCFGFSVTGV ASAEVPIIRV KDNAETSSSS
TSSTHGKEVY TDYSVTGIPG DGRCLFRSVV HGACIRSGRP IPNEDLQRKL ADELRATVAD
EFVKRRKETE WFVEGDFDTY VSHIREPHVW GGEPELFMAS HVLQMPITVY MRDEDAGGLI
AIAEYGQQYG KEDPIQVLYH GFGHYDALQI PAKVGSKRKL
//