ID   C0JPA2_TRIAD            Unreviewed;       625 AA.
AC   C0JPA2;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012418};
DE            EC=2.7.7.6 {ECO:0000256|ARBA:ARBA00012418};
DE   Flags: Fragment;
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:ACJ72070.1};
RN   [1] {ECO:0000313|EMBL:ACJ72070.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19175291; DOI=10.1371/journal.pbio.1000020;
RA   Schierwater B., Eitel M., Jakob W., Osigus H.J., Hadrys H.,
RA   Dellaporta S.L., Kolokotronis S.O., Desalle R.;
RT   "Concatenated analysis sheds light on early metazoan evolution and fuels a
RT   modern 'urmetazoon' hypothesis.";
RL   PLoS Biol. 7:E20-E20(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550};
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC       {ECO:0000256|ARBA:ARBA00006460}.
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DR   EMBL; FJ387016; ACJ72070.1; -; mRNA.
DR   AlphaFoldDB; C0JPA2; -.
DR   HOGENOM; CLU_000487_0_1_1; -.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 1.10.132.30; -; 1.
DR   Gene3D; 2.40.40.20; -; 1.
DR   Gene3D; 6.10.250.2940; -; 1.
DR   Gene3D; 6.20.50.80; -; 1.
DR   Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR   InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR   InterPro; IPR000722; RNA_pol_asu.
DR   InterPro; IPR006592; RNA_pol_N.
DR   InterPro; IPR007066; RNA_pol_Rpb1_3.
DR   InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR   InterPro; IPR007083; RNA_pol_Rpb1_4.
DR   InterPro; IPR007081; RNA_pol_Rpb1_5.
DR   InterPro; IPR007075; RNA_pol_Rpb1_6.
DR   InterPro; IPR038120; Rpb1_funnel_sf.
DR   PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR   PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR   Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR   Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR   Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR   Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR   Pfam; PF04992; RNA_pol_Rpb1_6; 1.
DR   SMART; SM00663; RPOLA_N; 1.
DR   SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE   2: Evidence at transcript level;
KW   DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1..76
FT                   /note="RNA polymerase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00663"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACJ72070.1"
FT   NON_TER         625
FT                   /evidence="ECO:0000313|EMBL:ACJ72070.1"
SQ   SEQUENCE   625 AA;  70420 MW;  559C3BBFCA48665F CRC64;
     VRILPWSTFR LNLSVTTPYN ADFDGDEMNL HVPQSLESRA EITEICMVPR QIVTPQSNKP
     VMGIVQDSLT AVRKFTMRDV FLEKEVVMNL LMWLPNWNGK MPQPAILRPK ELWTGKQIFS
     LIIPGNVNLI RTHSTHPDDE DKGPYKFISP GDTKVLIEHG EVISGILCKR TLGTSSGSLV
     HVIFNELGHE IARQFYGNIQ TVVNNWLLIE GHSIGIGDSI ADEATYQDIQ STILKAKQDV
     VEVIEKAHND ELEPTPGNTL RKTFENQVNR ILNDARDKTG SSAQKSLSNF NNFKAMVVAG
     SKGSKINISQ VIAVVGQQNV EGKRIPFGFR HRTLPHFIQD DYGPESRGFV ENSYLAGLTP
     TEFFFHAMGG REGLIDTAVK TAETGYIQRR LIKAMEGVMV HYDGTVRNAN MQLIQLCYGE
     VGLDGSAIEF QDMPSLKLSH TGFQRRFRFD IQNEKRLKQY LHGNIVRSII TDAEVKEKLQ
     SEFEQLSKDR NAVRSILQNG DSRVALPVNL NRLIWNAQKI FHVDPRKSSD LHPMKVIDDV
     CELSRKLVIV HGEDRISKQA QENATLLFNI LLRSVLSSKR VTEEYHLTSE AFDWLIGEVE
     SRFQQSQVQP GEMVGPLAAQ SLGEP
//