ID C0JTC6_XENLA Unreviewed; 378 AA.
AC C0JTC6;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Nodal-related 6a {ECO:0000313|EMBL:ACN49119.1};
GN Name=nr6a {ECO:0000313|EMBL:ACN49119.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:ACN49119.1};
RN [1] {ECO:0000313|EMBL:ACN49119.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19334278; DOI=10.1002/dvdy.21931;
RA Blythe S.A., Reid C.D., Kessler D.S., Klein P.S.;
RT "Chromatin immunoprecipitation in early Xenopus laevis embryos.";
RL Dev. Dyn. 238:1422-1432(2009).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; FJ468558; ACN49119.1; -; Genomic_DNA.
DR AlphaFoldDB; C0JTC6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13759; TGF_beta_NODAL; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF159; NODAL HOMOLOG; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..378
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002899225"
FT DOMAIN 250..378
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 378 AA; 43316 MW; F023A35A5D8CCB05 CRC64;
MALVNLVLSS IIFSLVQGIP TPVLTRSKVA LRPSTSIYGS RHSQGMKYPL YMMELYQTLI
MGNATDLSVL EHPALQESDA VLSLISKSCV EVDNHWALSF DMSSISSSNE LNLAELRIHM
PFFEKSHNVT IEIYHTKDRH ENFFLGSFQY DPSVAQGSSW KVFNITKMMQ NYLQLRDHFE
SEGYLRTKNM SRTARKISCT NVVAERVMLV VFAKDKPSAM SDSHQSLIKT VESSKYVKIE
EGTSFPGTRR HKRNRNVQHS IMRNKFLSRP KDNGKPLCRR VDMIVDFDKI GWGHHIIYPK
RFNAFRCEGS CPIPLNESFK PTNHAYIKSL VKLYDSDRVE CNSCVPVKMS PLSMLMYEDN
EVVLKHHEDM IVEECGCN
//
