ID C0KGB4_ARALP Unreviewed; 670 AA.
AC C0KGB4;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 28-JUN-2023, entry version 58.
DE SubName: Full=MEDEA {ECO:0000313|EMBL:ACN86196.1};
DE Flags: Fragment;
GN Name=MEDEA {ECO:0000313|EMBL:ACN86196.1};
OS Arabidopsis lyrata subsp. petraea (Northern rock-cress) (Cardaminopsis
OS petraea).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=59691 {ECO:0000313|EMBL:ACN86196.1};
RN [1] {ECO:0000313|EMBL:ACN86196.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PlA {ECO:0000313|EMBL:ACN86196.1};
RX PubMed=19126870; DOI=10.1093/molbev/msp001;
RA Miyake T., Takebayashi N., Wolf D.E.;
RT "Possible diversifying selection in the imprinted gene, MEDEA, in
RT Arabidopsis.";
RL Mol. Biol. Evol. 26:843-857(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR EMBL; FJ600432; ACN86196.1; -; Genomic_DNA.
DR AlphaFoldDB; C0KGB4; -.
DR GO; GO:0031519; C:PcG protein complex; IEA:InterPro.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10519; SET_EZH; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR025778; Hist-Lys_N-MeTrfase_plant.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF7; HISTONE-LYSINE N-METHYLTRANSFERASE MEDEA; 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01114; CXC; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS51576; SAM_MT43_EZ; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 409..513
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 525..640
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 150..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..167
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACN86196.1"
SQ SEQUENCE 670 AA; 77159 MW; 36F300212952E5CB CRC64;
DNHEDDGEDL PPEINQIKEQ IEKERFQHIK KTFELRCIPS VAAHASHHQS FDLNQPLAED
DNEGDNKTLL SRMQNPLHHF SALSDSDTYE DQRCVFNKEA PLFPSVNLPV VEQLPRSLTW
VFIKSSQLMA ESDSVIGKRQ IYYLNGEALE LSSEEDEEDE EEDEEETKKE KCEFSKDVDR
FIWTVGQDYG LDDLVVQRAL AKFLEVEVSD ILERYNELKL KNDETVGEAS DLTSKTITTA
FQDFADRRRH CRRCLIFDCH MHEKFEPEFR PTEDKSGLFE NEDRQPCSEH CYLKVRSVTA
DHAVDNDNSI INKNVVSDPN KTMWTPVEKD LYLKGVQIFG RNSCVITLNI LRGLKTCLEV
YNYMLEQDQC TMSLVLHKTT KTKNQVNKKV SRKGTRSVRK KSRLRKYARY PPALKKTTNG
EAKFYKHYTP CTCKSKCGYQ CPCLTNENCC EKYCGCPKDC NNRFGGCNCA IGQCTNRQCP
CFAANRECDP DLCRSCPLSC GDGSLGEPSE QIQCKNMHFL LKKNKKILIG KSNVHGWGAF
TPDSLKKNEF LGEYTGELIT HEEANERGRV EDRIGSSYLF TLNDQLEIDA RRYGNKFKFL
NHSARPNCYA KLMIVRGDQR IGLFAERAIE QNEELFFDYC YGPEHADWSR GREPRKTGAS
KRSKEARPSR
//
