ID C0KIP5_ONCMY Unreviewed; 233 AA.
AC C0KIP5;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 22-FEB-2023, entry version 41.
DE RecName: Full=Thymidine kinase {ECO:0000256|RuleBase:RU000544};
DE EC=2.7.1.21 {ECO:0000256|RuleBase:RU000544};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:ACM80353.1};
RN [1] {ECO:0000313|EMBL:ACM80353.1}
RP NUCLEOTIDE SEQUENCE.
RA Wang J.Q., Li L.C., Lin S.G.;
RT "Cloning and characterization of the thymidine kinase gene in rainbow trout
RT (Oncorhynchus mykiss).";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21;
CC Evidence={ECO:0000256|ARBA:ARBA00033702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19130;
CC Evidence={ECO:0000256|ARBA:ARBA00033702};
CC -!- SIMILARITY: Belongs to the thymidine kinase family.
CC {ECO:0000256|ARBA:ARBA00007587, ECO:0000256|RuleBase:RU004165}.
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DR EMBL; FJ607866; ACM80353.1; -; mRNA.
DR RefSeq; NP_001153968.1; NM_001160496.1.
DR AlphaFoldDB; C0KIP5; -.
DR GeneID; 100301667; -.
DR KEGG; omy:100301667; -.
DR CTD; 7083; -.
DR OrthoDB; 674053at2759; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001267; Thymidine_kinase.
DR InterPro; IPR020633; Thymidine_kinase_CS.
DR PANTHER; PTHR11441; THYMIDINE KINASE; 1.
DR PANTHER; PTHR11441:SF0; THYMIDINE KINASE, CYTOSOLIC; 1.
DR Pfam; PF00265; TK; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000544};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW ECO:0000256|RuleBase:RU000544};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU000544};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000544};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000544}.
SQ SEQUENCE 233 AA; 25965 MW; 72E22204A573CAC3 CRC64;
MECLNVPRIL PNSPRKAIGQ IQVIFGPMFS GKSTELIRRV RRFQIAQYNC LVVKYAKDTR
YSEKGMATHD KNTMEAVPAN CLSDVRSLAL QACVIGIDEG QFFPDIVQFC EEMANMGKTI
IVAALDGTFQ RKPFGDILNL VPLAESVVKL NAVCMQCYKE AAYTKRLGAE KEVEVIGGAD
MYHARCRKCY GGLMDVLKEN SAPHRDETPP HVMTGKLLDN TTSPRKLFAT LQL
//
