ID C0KXK7_HPV16 Unreviewed; 151 AA.
AC C0KXK7;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Protein E6 {ECO:0000256|RuleBase:RU363123};
DE Flags: Fragment;
GN Name=E6 {ECO:0000313|EMBL:ACN22507.1};
OS Human papillomavirus type 16.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC Alphapapillomavirus; Alphapapillomavirus 9.
OX NCBI_TaxID=333760 {ECO:0000313|EMBL:ACN22507.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACN22507.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TV338a {ECO:0000313|EMBL:ACN22507.1};
RX PubMed=19626616; DOI=10.1002/jmv.21552;
RA Cento V., Ciccozzi M., Ronga L., Perno C.F., Ciotti M.;
RT "Genetic diversity of human papillomavirus type 16 E6, E7, and L1 genes in
RT Italian women with different grades of cervical lesions.";
RL J. Med. Virol. 81:1627-1634(2009).
CC -!- FUNCTION: Plays a major role in the induction and maintenance of
CC cellular transformation. {ECO:0000256|RuleBase:RU363123}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000256|RuleBase:RU363123}.
CC Host nucleus {ECO:0000256|RuleBase:RU363123}.
CC -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC {ECO:0000256|ARBA:ARBA00006346, ECO:0000256|RuleBase:RU363123}.
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DR EMBL; FJ644969; ACN22507.1; -; Genomic_DNA.
DR SMR; C0KXK7; -.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR GO; GO:0039548; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.240.40; E6 early regulatory protein; 2.
DR HAMAP; MF_04006; HPV_E6; 1.
DR InterPro; IPR001334; E6.
DR InterPro; IPR038575; E6_sf.
DR Pfam; PF00518; E6; 1.
DR SUPFAM; SSF161229; E6 C-terminal domain-like; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU363123};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU363123};
KW Early protein {ECO:0000256|ARBA:ARBA00022518,
KW ECO:0000256|RuleBase:RU363123};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host nucleus {ECO:0000256|RuleBase:RU363123};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host IRF3 by virus {ECO:0000256|ARBA:ARBA00022931};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU363123};
KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU363123};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU363123};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU363123};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU363123}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACN22507.1"
FT NON_TER 151
FT /evidence="ECO:0000313|EMBL:ACN22507.1"
SQ SEQUENCE 151 AA; 18320 MW; 617D2A2FDB4F8C17 CRC64;
MFQDPQERPR KLPQLCTELQ TTIHDIILEC VYCKQQLLRR EVYDFAFRDL CIVYRDGNPY
AVCDKCLKFY SKISEYRHYC YSVYGTTLEQ QYNKPLCDLL IRCINCQKPL CPEEKQRHLD
KKQRFHNIRG RWTGRCMSCC RSSRTRRETQ L
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