ID C0L356_HHV1 Unreviewed; 376 AA.
AC C0L356;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Thymidine kinase {ECO:0000313|EMBL:ACN54633.1};
DE Flags: Fragment;
OS Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha1.
OX NCBI_TaxID=10298 {ECO:0000313|EMBL:ACN54633.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACN54633.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=R13A:296Fs->376 {ECO:0000313|EMBL:ACN54633.1};
RX PubMed=19795980; DOI=10.1086/606028;
RA Duan R., de Vries R.D., van Dun J.M., van Loenen F.B., Osterhaus A.D.,
RA Remeijer L., Verjans G.M.;
RT "Acyclovir susceptibility and genetic characteristics of sequential herpes
RT simplex virus type 1 corneal isolates from patients with recurrent herpetic
RT keratitis.";
RL J. Infect. Dis. 200:1402-1414(2009).
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DR EMBL; FJ655150; ACN54633.1; -; Genomic_DNA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006230; P:TMP biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_04029; HSV_KITH; 1.
DR InterPro; IPR001889; Herpes_TK.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00693; Herpes_TK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACN54633.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACN54633.1}.
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 376
FT /evidence="ECO:0000313|EMBL:ACN54633.1"
SQ SEQUENCE 376 AA; 40815 MW; AA50425E26E3CBB9 CRC64;
MASYPGHQHA SAFDQAARSR GHSNRRTALR PRRQQEATEV HLEQKMPTLL RVYIDGPHGM
GKTTTTQLLV ALGSRDDIVY VPEPMTYWRV LGASETIANI YTTQHRLDQG EISAGDAAVV
MTSAQITMGM PYAVTDAVLA PHIGGEAGSS HAPPPALTLI FDRHPIAALL CYPAARYLMG
SMTPQAVLAF VALIPPTLPG TNIVLGALPE DRHIDRLAKR QRPGERLDLA MLAAIRRVYE
LLANTVRYLQ GGGSWREDWG QLSGTAVPPQ GAEPQSNAGP QPHIGDTLFT LFRAPSCWPP
TATCITCLPG PWTSWPNASV PCTSLSWITT NRPPAAGTPC CNLPPGWSRP TSPPPAPYRR
SATWRARLPG RWGRLT
//
