ID C0LF60_CAPAN Unreviewed; 386 AA.
AC C0LF60;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 22-FEB-2023, entry version 46.
DE RecName: Full=chalcone synthase {ECO:0000256|ARBA:ARBA00012975};
DE EC=2.3.1.74 {ECO:0000256|ARBA:ARBA00012975};
DE Flags: Fragment;
GN Name=CHS {ECO:0000313|EMBL:ACN60400.1};
OS Capsicum annuum (Capsicum pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=4072 {ECO:0000313|EMBL:ACN60400.1};
RN [1] {ECO:0000313|EMBL:ACN60400.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Fruit pericarp {ECO:0000313|EMBL:ACN60400.1};
RA Aza-Gonzalez C., Herrera-Isidron L., Nunes-Palenius H.G.,
RA Martinez-de-la-Vega O., Ochoa-Alejo N.;
RT "Anthocyanin accumulation and expression analysis of biosynthesis-related
RT genes during chili pepper fruit development.";
RL Biol. Plant. 57:49-55(2013).
CC -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC which can under specific conditions spontaneously isomerize into
CC naringenin. {ECO:0000256|ARBA:ARBA00002969}.
CC -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004966}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|RuleBase:RU003633}.
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DR EMBL; FJ705842; ACN60400.1; -; mRNA.
DR AlphaFoldDB; C0LF60; -.
DR UniPathway; UPA00154; -.
DR GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF94; CHALCONE SYNTHASE 2; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003633};
KW Flavonoid biosynthesis {ECO:0000256|ARBA:ARBA00023241};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003633}.
FT DOMAIN 5..228
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 238..386
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 164
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
FT NON_TER 386
FT /evidence="ECO:0000313|EMBL:ACN60400.1"
SQ SEQUENCE 386 AA; 42493 MW; 850D05513954A166 CRC64;
MVTVEEVRRE QRAKGPATIM AIGTATPSNC VDQATYPDYY FRITNSEHMT ELKEKFQRMC
DKSMIKKRYM HLTEEILKEN PNICEYMAPS LDARQDIVVV EIPKLGKEAA KKAIKEWGQP
KSKITHLVFC TTSGVDMPGA DYQLTKLLGL RPSVKRLMMY QQGCFAGGTV IRLAKDLAEN
NKGARVLVVC SEITAVTFRG PSDTHLDSMV GQALFGDGAA ALIVGSDPLP EVERPLFELV
SAAQTLLPDS EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLIEAFQPL GNSDWNSIFW
IAHPGGPTIL DQVELKLGLK LEKLRATRQV LSDYGNMSRA CVLFILDEMR KASAKEGLNT
TGEGLDWGVL FGFGPGLTVE TVVLHS
//
