ID C0LTV3_9PLVG Unreviewed; 832 AA.
AC C0LTV3;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ACN76715.1};
OS Simian-Human immunodeficiency virus.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus;
OC Primate lentivirus group.
OX NCBI_TaxID=57667 {ECO:0000313|EMBL:ACN76715.1};
RN [1] {ECO:0000313|EMBL:ACN76715.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AL01day28env {ECO:0000313|EMBL:ACN76715.1};
RX PubMed=19279098; DOI=10.1128/JVI.00055-09;
RA Dudley D.M., Wentzel J.L., Lalonde M.S., Veazey R.S., Arts E.J.;
RT "Selection of a simian-human immunodeficiency virus strain resistant to a
RT vaginal microbicide in macaques.";
RL J. Virol. 83:5067-5076(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; FJ768975; ACN76715.1; -; Other_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR HAMAP; MF_04083; HIV_ENV; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR037527; Gp160.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 2.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Clathrin-mediated endocytosis of virus by host
KW {ECO:0000256|ARBA:ARBA00022570};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host endosomal membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ACN76715.1};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022570};
KW Virion {ECO:0000313|EMBL:ACN76715.1};
KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00022570}.
FT TRANSMEM 488..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..126
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 134..487
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 506..695
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 699..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..719
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACN76715.1"
SQ SEQUENCE 832 AA; 93968 MW; 3A734CA386A0A194 CRC64;
GGTLLLGMLM ICSAVEKLWV TVYYGVPVWK EATTTLFCAS DAKAYDTEVH NVWATHACVP
TDPNPQEIVL ENVTENFNMW KNNMVEQMHE DIISLWDQSL KPCVKLTPLC VTLHCTNLEN
ATNTTSSNWK EMNRGEIKNC SFNVTTSIGN KMQKEYALFY KLDVVPIDND NTSYNLINCN
TSVITQACPK VSFEPIPIHY CAPAGFAILK CNDKKFNGSG PCINVSTVQC THGIRPVVST
QLLLNGSLAE EGVVIRSENF TDNVKTIIVQ LKESVEVNCT RPNNNTRKSI PIGPGKAFYA
TGDIIGDIRQ AHCNISGEKW NNTLKQIVTK LQAQFENKTI VFKQSSGGDP EIVMHSFNCG
GEFFYCNSTQ LFNSTWNNTI GPNNTNGTIT LPCRIKQIIN RWQEVGKAMY APPIRGQIRC
SSNITGLLLT RDGGREVSNT TEIFRPGGGD MRDNWRSELY KYKVVKIEPL GVAPTKAKRR
VVQREKRAVT LGAVFLGFLG AAGSTMGAAS LTLTVQARQL LSGIVQQQNN LLRAIEAQQH
LLQLTVWGIK QLQARVLAVE RYLKDQQLLG IWGCSGKLIC TTAVPWNASW SNKSLDQIWN
NMTWMEWERE IGNYTNLIYT LIEESQNQQE KNEQELLELD KWASLWNWFD ISKWLWYIKI
FIIIVGGLIG LRIVFTVLSI VNRVRQGYSP LSFQTRFPAP RGLDRPEGIE EEGGERDRDR
SRPLVHGLLA LIWDDLRSLC LFSYHRLRDL ILIAARIVEL LGRRGWEALK YWGNLLQYWI
QELKNSTVSL FGAIAIAVAE GTDRIIEVAQ RIGRAFLHIP RRIRQGLERT LL
//
