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Database: UniProt
Entry: C0N2X9_9GAMM
LinkDB: C0N2X9_9GAMM
Original site: C0N2X9_9GAMM 
ID   C0N2X9_9GAMM            Unreviewed;       418 AA.
AC   C0N2X9;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   25-OCT-2017, entry version 61.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
DE   Flags: Fragment;
GN   Name=dnaA_2 {ECO:0000313|EMBL:EEF80848.1};
GN   ORFNames=MDMS009_575 {ECO:0000313|EMBL:EEF80848.1};
OS   Methylophaga thiooxydans DMS010.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Piscirickettsiaceae; Methylophaga.
OX   NCBI_TaxID=637616 {ECO:0000313|EMBL:EEF80848.1, ECO:0000313|Proteomes:UP000004679};
RN   [1] {ECO:0000313|EMBL:EEF80848.1, ECO:0000313|Proteomes:UP000004679}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DMS010 {ECO:0000313|EMBL:EEF80848.1,
RC   ECO:0000313|Proteomes:UP000004679};
RX   PubMed=21478352; DOI=10.1128/JB.00388-11;
RA   Boden R., Ferriera S., Johnson J., Kelly D.P., Murrell J.C.,
RA   Schafer H.;
RT   "Draft genome sequence of the chemolithoheterotrophic, halophilic
RT   methylotroph Methylophaga thiooxydans DMS010.";
RL   J. Bacteriol. 193:3154-3155(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; GG657888; EEF80848.1; -; Genomic_DNA.
DR   RefSeq; WP_008290349.1; NZ_GG657888.1.
DR   ProteinModelPortal; C0N2X9; -.
DR   STRING; 637616.MDMS009_575; -.
DR   EnsemblBacteria; EEF80848; EEF80848; MDMS009_575.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   Proteomes; UP000004679; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004679};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004679}.
FT   DOMAIN      115    243       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      326    395       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:EEF80848.1}.
SQ   SEQUENCE   418 AA;  46710 MW;  52C16FE78999817F CRC64;
     LLAPNPYVKA WVQEQLESQI NTLIAALSQG SIDKVAIEVG TKAMGNMPSR RQTDATEPET
     TTPLVNSKPS ETKAEPAIGN PMNPLFTFDS YVEGKSNQIA RAASLHVAEA PGTSGYNPLF
     LYGGTGLGKT HLMLAVGNKI KQDNPKARVI YLSSERFVQD MITALRNNAI DQFKSHYRSA
     DALLIDDIQF FAKKERSQEE FFYTFNSLLE GQRQIILTCD RFPKEVENLD ERLQSRLGWG
     LTVAIEPPEL ETRVAILIKK AQQNLITLPE DVAFFIAKRI KSNVRDLEGA LQRVLAFSRF
     TNQPLSIDMA QEALKDLLAL HQKLVTLESI QKTVGEYFKV RVSDLLAKKR TRSIARPRQI
     AMALAKELTS HSLPEIGDAF GGRDHTTVLH ACRKVAELKE SDTRVAEDYR NLLRTLSS
//
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