ID C0N6U4_9GAMM Unreviewed; 749 AA.
AC C0N6U4;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:EEF79322.1};
GN ORFNames=MDMS009_1909 {ECO:0000313|EMBL:EEF79322.1};
OS Methylophaga thiooxydans DMS010.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Piscirickettsiaceae; Methylophaga.
OX NCBI_TaxID=637616 {ECO:0000313|EMBL:EEF79322.1, ECO:0000313|Proteomes:UP000004679};
RN [1] {ECO:0000313|EMBL:EEF79322.1, ECO:0000313|Proteomes:UP000004679}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DMS010 {ECO:0000313|EMBL:EEF79322.1,
RC ECO:0000313|Proteomes:UP000004679};
RX PubMed=21478352; DOI=10.1128/JB.00388-11;
RA Boden R., Ferriera S., Johnson J., Kelly D.P., Murrell J.C., Schafer H.;
RT "Draft genome sequence of the chemolithoheterotrophic, halophilic
RT methylotroph Methylophaga thiooxydans DMS010.";
RL J. Bacteriol. 193:3154-3155(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG657899; EEF79322.1; -; Genomic_DNA.
DR RefSeq; WP_008291408.1; NZ_GG657899.1.
DR AlphaFoldDB; C0N6U4; -.
DR HOGENOM; CLU_010363_3_0_6; -.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000004679; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 507..693
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 749 AA; 84318 MW; B3AF2E3BFA32CAC5 CRC64;
MIKTAMAFLL GCLLCLSLKE MPAPNGFLLL VVIIVLWLRH TVGLAFIVGL LWAGFQAQSQ
LADRLPETLA GKDIVISGEI TTIPTVRDRL VRFELAPDSS AYPRRIRLTW YRASNPYPNA
GEHWQFTVRL KPPRGMSNPG SFDYEKWLFT QRIGATGYVR DSTSNQLLQH ASVWDVNRLR
QQLQVRLKKL LPDAEQLPLL QGLAIGIRDD LDDSHWQTLR QTGTSHLLAI SGLHIGLAAA
IGFFLLRFLW SLMPSLLLRV PAHYVGALGG VILAAFYACL AGFTVPTQRA FVMVATIMLA
LVWKRPLYPL HVLAVSLLLV LFIDPFAVIS AGFWLSFSAV ALIVFTCSNR YPKQRWNWAG
IHLWIAVGLI PLLVLFFGQI SVISPIANFI AVPLVSFLVV PIILFGMVML IVSEPLARWL
LNNADYLLDL MWQWLRLLAN SPISDWHSPF LPIVMIGFVA IAVILILLPR GWPAKWLALI
LLLPIWFYQP DKPESGEFYL SVLDVGQGLA TVIETKDHVL VFDTGPKYSA YFDTGKAVVA
PYLKHRAINN VDKLIVSHSD NDHIGGVDSL ADLVTINETY SSDLEALPNA TPCLAGQVWF
WNQVKFEILH PFETKLTSNN NNRSCVLKVT ANNRSALLPG DIEKESEYRL LNRYGKALKA
DILVVPHHGS RTSSTMRFIQ TVDPEYGLLA VGYRNRYRFP VESVLKRYQK QGTNLLRTDH
HGAILFRDET QPIRWRQQNA KLWTSKATE
//
