ID C0NPY7_AJECG Unreviewed; 1388 AA.
AC C0NPY7;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Cation-transporting ATPase {ECO:0000313|EMBL:EEH06997.1};
GN ORFNames=HCBG_05217 {ECO:0000313|EMBL:EEH06997.1};
OS Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS (Darling's disease fungus) (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH06997.1, ECO:0000313|Proteomes:UP000001631};
RN [1] {ECO:0000313|Proteomes:UP000001631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC {ECO:0000313|Proteomes:UP000001631};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type V subfamily. {ECO:0000256|ARBA:ARBA00006000}.
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DR EMBL; GG663368; EEH06997.1; -; Genomic_DNA.
DR AlphaFoldDB; C0NPY7; -.
DR STRING; 447093.C0NPY7; -.
DR VEuPathDB; FungiDB:I7I50_04554; -.
DR HOGENOM; CLU_001828_4_0_1; -.
DR InParanoid; C0NPY7; -.
DR OrthoDB; 6047at2759; -.
DR Proteomes; UP000001631; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0140358; F:P-type transmembrane transporter activity; IEA:InterPro.
DR CDD; cd07543; P-type_ATPase_cation; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006544; P-type_TPase_V.
DR InterPro; IPR047820; P5A-type_ATPase.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR NCBIfam; TIGR01657; P-ATPase-V; 1.
DR PANTHER; PTHR45630; CATION-TRANSPORTING ATPASE-RELATED; 1.
DR PANTHER; PTHR45630:SF7; ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01229; COF_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 138..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1388 AA; 155064 MW; 8D984EAAE3D5F141 CRC64;
MWEDWTKEIG GLEAVRKNDC RRFPGESSGT LRRLRRKTIA SGSSEGLVRL NGTRILETSL
RSINNCEPFI FSREILALTL PLALLPRCIL SWDLVYVYQL YLPDRASRAS SGIMPRLVDN
SQIQSASLHN PLPLQLHAYV WPFLIIWPTF LAVYLSPERY DTYIQGSEWT FLWAGGIFTL
QALVWLSTKW NVNVQALFTT STAKSVYSAK LIKVSPVVNA GSAEICPLLR EKYAGKDDIS
FLFQKRRFLY YPDRNTFAPL SYAIDAEPKP LLKTFQHSQG LKTDKEIGEN QNHYGDNTFD
IPVPTFTELF KEHAVAPFFV FQVFCVGLWL LDEYWYYSLF TLLMLVTFES TVVWQRQRTL
NEFRGMSIKP YEVWVYRKNA WTEITSDKLL PGDVLSVNRT REDSGVACDI LMIEGSVIVN
EAMLSGESTP LLKDSIQLRP EDDQLDPEGL DKNSFLYGGT KVLQITHPNS TASPPNGIPT
PPDNGALGVV VKTGFETSQG SLVRTMIYST ERVSANNVEA LLFILFLLMF AIAASWYVWQ
EGVAKDRKRS KLLLDCVLII TSVVPPELPM ELSLAVNTSL AALSKFAIFC TEPFRIPYAG
RIDIACFDKT GTLTGEDLLV DGIAGLTLGH ASAKTDKHGA HTDITPVEKV ANETTLVLAT
AHALVKLDEG EIVGDPMEKA TLNSLGWVLG RDDILTSKAT GASRQPGRAL DSVQIKRRFQ
FSSALKRQSA IATVISTDRQ TSKKLRGTFV GVKGAPETIR TMLVSTPPYY EETFKYFTRN
GARVLALGYK YLSTESELGQ GRINNLKRED VESELHFAGF LVLQCPLKDD AVKALRMLNE
SNHRVVMITG DNPLTAAHVA RQVEIVDREV LILDAPENDN SGTKLVWRTI DDSFSVDVDP
TQPLDREILE TKDLCVTGYA LTKFKNKKAL PDLLRHTWVY ARVSPKQKED ILLGMKDAGY
TTLMCGDGTN DVGALKQAHV GVALLNGSQD DLNKIAEHWR NTKMKEIYEK QVSLMQRFNQ
PAPPIPANIA HLYPPGPNNP HYEKALIREA QRKGITAPAA IGGNGIPTVT SPGAHAIQQS
TMNLTPQQRQ QRHASLAAAG FADKLTATMM EQELDDNEPP TIKLGDASVA APFTSKLANV
IAIPNIIRQG RCTLVATIQM YKILALNCLI SAYSLSVIYL DGIRFGDGQA TISGILMSVC
FLSISRAKSV EGLSKERPQP NIFNMYIMGS VLGQFAVHVA TLIYLSNYVY TIEPAIYLLQ
LIQQISTFSI NYQGRPFRES IRENRGMYWG LILTSGVAFS CATEFIPELN EKLRLVPFTT
MFKVTLTALM LADYAGCWLI ENILKTYFSD YRPKDIAVRR PDQLAWEEER KRKEAVAEEN
EKESKRKV
//
