ID   C0NQL2_AJECG            Unreviewed;       337 AA.
AC   C0NQL2;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Zeta-crystallin/quinone reductase (NADPH) {ECO:0000313|EMBL:EEH05976.1};
GN   ORFNames=HCBG_05292 {ECO:0000313|EMBL:EEH05976.1};
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH05976.1, ECO:0000313|Proteomes:UP000001631};
RN   [1] {ECO:0000313|Proteomes:UP000001631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC   {ECO:0000313|Proteomes:UP000001631};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG663369; EEH05976.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NQL2; -.
DR   STRING; 447093.C0NQL2; -.
DR   VEuPathDB; FungiDB:I7I50_04016; -.
DR   HOGENOM; CLU_026673_3_4_1; -.
DR   InParanoid; C0NQL2; -.
DR   OrthoDB; 2598390at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd05276; p53_inducible_oxidoreductase; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR014189; Quinone_OxRdtase_PIG3.
DR   NCBIfam; TIGR02824; quinone_pig3; 1.
DR   PANTHER; PTHR48106:SF8; QUINONE OXIDOREDUCTASE PIG3; 1.
DR   PANTHER; PTHR48106; QUINONE OXIDOREDUCTASE PIG3-RELATED; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001631}.
FT   DOMAIN          14..332
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   337 AA;  36566 MW;  F1D03FFC8EB2CCF8 CRC64;
     MASMRAIDIK GGKGPAANLF INTIPKPLPA AGEALVKIKA FGLNRMDLLQ REGMYPVPPQ
     APKTLGVEFS GVIESLGDGD CLDFKVGDEV FGLAYGGAYA EYISSSVQTL LHKPAELSWI
     EAAGIPETWF TAAQAMYLVG EFKPGKSILW HAGASAVSIS GIQLSKADNA SNIYVTAGSQ
     EKIDFCVKDL GATAGFNYKT QDWVSELSKV TNGRGVDVIV DFVGASYFQG NLDAAAKDGR
     IVNLGFLGGT KLPAGIDISQ ILRKRLRYEG SSLRSRDIAY QRQLRDLLLD HAMPKFREGT
     FKIYVERVFP FEKVIDAHLL MESNQTKGKI ICTITES
//