ID C0NWU6_AJECG Unreviewed; 1258 AA.
AC C0NWU6;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Peroxisomal ATPase PEX1 {ECO:0000256|ARBA:ARBA00034532};
DE AltName: Full=Peroxin-1 {ECO:0000256|ARBA:ARBA00032509};
GN ORFNames=HCBG_07626 {ECO:0000313|EMBL:EEH04401.1};
OS Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS (Darling's disease fungus) (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH04401.1, ECO:0000313|Proteomes:UP000001631};
RN [1] {ECO:0000313|Proteomes:UP000001631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC {ECO:0000313|Proteomes:UP000001631};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG663374; EEH04401.1; -; Genomic_DNA.
DR AlphaFoldDB; C0NWU6; -.
DR STRING; 447093.C0NWU6; -.
DR VEuPathDB; FungiDB:I7I50_08149; -.
DR HOGENOM; CLU_000688_1_0_1; -.
DR InParanoid; C0NWU6; -.
DR OrthoDB; 544017at2759; -.
DR Proteomes; UP000001631; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0007031; P:peroxisome organization; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd19526; RecA-like_PEX1_r2; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.10.330.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR029067; CDC48_domain_2-like_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015342; PEX1-N_C-lobe.
DR PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR PANTHER; PTHR23077:SF12; PEROXISOME BIOGENESIS FACTOR 1; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF09262; PEX-1N; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF54585; Cdc48 domain 2-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 559..714
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 883..1018
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 226..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1091
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1258 AA; 135645 MW; 82F5EB8EACF4334E CRC64;
MAPGNRKTST TAEVVLVPLK NCLANLPPSL VTLLVNANTP AQNVVVELQY RPASSTSTAS
QLQRCAYVGW TGMPSKRRFA PVVSKDGISG VRDFSREQEI PTVEIDSTFG RVLGLSDGQR
VGLLLHLDPL VAHTVNIEPL TPADWEIIEL HATFLELNLL SQIRALPNPA YSGTTVGQIS
HSHPLTLHLS PTSTANITIT SLTPPAPANS PFAKIAQDAE VVVAPKVRPK SSGHSRSENR
STTSTGWKSV SGRSSGSTVR PKSNHSDSAL HGAVYLRSVD RRHTQDWFDE DSDTQKNEGF
RIWIDRGILE KNELRGTVWA CVSIVTPAGL LPPVDPQQQL QKKEQESSDA GKPSKKIVAR
VLTWDESPDC QHVALSSHLC SALGSDGMVG GIVRVEAAPP QIPHSSVKSI KIFPFASSFS
NKKDGLKFGG DSSAYRDSLS ERIKLLYGSP GSDSGMLSGA ITDGMILPKL ENQAASLELE
GGIVRFDPPL NPSSETNKVA FGWLLGSECK IDLDIQPEIT KPQDSVPSFA PSTDPIPDDA
PDLVGIDTVI ENCLSNLTRS SSILLTGGLG AGKTSLCQLL AHNLREDYLF NVSFFSCRKL
VTHETRISTI KETFHRLFLS ASWCARQGGQ SLVILDDLDR LCPVETELQV GGENGRSRQI
SEIVCLTVRE FCSANSSVVL LATAQAKESL NNVIVGGHVV REIISLKAPN KDGRRMVLEK
LTAADGPVTR FQNVVNGHLR NQSSSTQDSW LEPSDPGSRP GSSGQSDGFI LSRDLDFLDL
AGKTDGYMPG DLVLLTARAR NEALIRSVQD TSSTSCAITL GTQDFSHALK GFTPASLRNV
TLTSSSTTFA SIGGLHETRK TLLETLQYPT TYAPIFAQCP LRLRSGLLLY GFPGCGKTLL
ASAVAGECGL NFISVKGPEI LNKYIGASEK SVRDLFERAE AARPCILFFD EFDSIAPKRG
HDSTGVTDRV VNQLLTQMDG AEGLSGVYVL AATSRPDLID PALLRPGRLD KSLLCDMPSH
SDRADIIQAL SKQLKLSEEV IARVDEIADR TKGYSGADLQ AVVYNAHLEA IHDALGDRSS
NSNNPQNRPK RPAITNGVIP VVNGNIKAST EKIAKKPFIQ FLYSSDEHAT AVVSRTRLIE
GSASSLPPPA VVAAKLDAIK QARKRQRQCQ QELEASDQLV NAASLGANGA TAADKDASDD
IYICWTHMER SLATTRCSIS DVERNRLEAI YKEFIVGRNG EMPTGEGGRE IGGRTSLM
//