ID C0P162_AJECG Unreviewed; 496 AA.
AC C0P162;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Folate carrier protein {ECO:0000313|EMBL:EEH02577.1};
GN ORFNames=HCBG_09142 {ECO:0000313|EMBL:EEH02577.1};
OS Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS (Darling's disease fungus) (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH02577.1, ECO:0000313|Proteomes:UP000001631};
RN [1] {ECO:0000313|Proteomes:UP000001631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC {ECO:0000313|Proteomes:UP000001631};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the Tom7 family.
CC {ECO:0000256|ARBA:ARBA00010917}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; GG663384; EEH02577.1; -; Genomic_DNA.
DR AlphaFoldDB; C0P162; -.
DR STRING; 447093.C0P162; -.
DR VEuPathDB; FungiDB:I7I50_09061; -.
DR HOGENOM; CLU_015166_6_4_1; -.
DR InParanoid; C0P162; -.
DR OrthoDB; 4772at2759; -.
DR Proteomes; UP000001631; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005742; C:mitochondrial outer membrane translocase complex; IEA:InterPro.
DR GO; GO:0006862; P:nucleotide transport; IEA:InterPro.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR044712; SLC25A32-like.
DR InterPro; IPR012621; Tom7.
DR PANTHER; PTHR45683:SF3; MITOCHONDRIAL FOLATE TRANSPORTER_CARRIER; 1.
DR PANTHER; PTHR45683; MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR Pfam; PF08038; Tom7; 1.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 21..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 187..276
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 289..376
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 407..489
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 496 AA; 55099 MW; 6C26E0145290C312 CRC64;
MVQFSEETKE RISKVIGISR VAIHYGYLPF IIYLGYTYSE PRPQLLKYVL SRSTLTVRKF
KRHKLTSTSR SQAFLALRMN STNFYEMTWM LAGFSRENAA VERINHNENV RPFVSDRVDS
RANLLYFKKR ANFILDLTEI QTTNTNNTTA TSVFEKNRNT VSWLWGEPKG PLRTSQNESM
NGNHGLSPSV VETIAGFAAG ISSTLVVHPL DVIKTRLQVD RFSTSRIGSS VRIARSIVQN
EGGIVTGFYR GLTPNIVGNS VSWGLYFLWY SNIKDTLHVL HGSRKEEGLG SLDYFAASGA
AGVLTAFLTN PIWVIKTRML STGSQVPGAY PSLVAGARSI YRSEGVMGFY RGMIPALFGV
SHGALQFMSY EKLKQCRAAP SSVVGMSGNG NANGGTTTKD LKLGNMDYLV LSGTSKVFAG
CVTYPYQVLK ARLQTYDAAG TYRGVIDAIG QIWRRERVMG FYKGLGPNLL RVLPSTWVTF
LVYENVRIHL LMGPVV
//
