ID C0QJP4_DESAH Unreviewed; 495 AA.
AC C0QJP4;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=succinyl-diaminopimelate desuccinylase {ECO:0000256|ARBA:ARBA00011921};
DE EC=3.5.1.18 {ECO:0000256|ARBA:ARBA00011921};
GN OrderedLocusNames=HRM2_07840 {ECO:0000313|EMBL:ACN13897.1};
OS Desulforapulum autotrophicum (strain ATCC 43914 / DSM 3382 / VKM B-1955 /
OS HRM2) (Desulfobacterium autotrophicum).
OC Bacteria; Thermodesulfobacteriota; Desulfobacteria; Desulfobacterales;
OC Desulfobacteraceae; Desulforapulum.
OX NCBI_TaxID=177437 {ECO:0000313|EMBL:ACN13897.1, ECO:0000313|Proteomes:UP000000442};
RN [1] {ECO:0000313|EMBL:ACN13897.1, ECO:0000313|Proteomes:UP000000442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43914 / DSM 3382 / HRM2
RC {ECO:0000313|Proteomes:UP000000442};
RX PubMed=19187283; DOI=10.1111/j.1462-2920.2008.01825.x;
RA Strittmatter A.W., Liesegang H., Rabus R., Decker I., Amann J., Andres S.,
RA Henne A., Fricke W.F., Martinez-Arias R., Bartels D., Goesmann A.,
RA Krause L., Puehler A., Klenk H.P., Richter M., Schuler M., Gloeckner F.O.,
RA Meyerdierks A., Gottschalk G., Amann R.;
RT "Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate
RT reducer oxidizing organic carbon completely to carbon dioxide.";
RL Environ. Microbiol. 11:1038-1055(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate =
CC (2S,6S)-2,6-diaminoheptanedioate + succinate; Xref=Rhea:RHEA:22608,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:30031, ChEBI:CHEBI:57609,
CC ChEBI:CHEBI:58087; EC=3.5.1.18;
CC Evidence={ECO:0000256|ARBA:ARBA00001246};
CC -!- COFACTOR:
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000256|ARBA:ARBA00001941};
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate
CC (succinylase route): step 3/3. {ECO:0000256|ARBA:ARBA00005130}.
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DR EMBL; CP001087; ACN13897.1; -; Genomic_DNA.
DR AlphaFoldDB; C0QJP4; -.
DR STRING; 177437.HRM2_07840; -.
DR KEGG; dat:HRM2_07840; -.
DR eggNOG; COG0624; Bacteria.
DR HOGENOM; CLU_550654_0_0_7; -.
DR OrthoDB; 9809784at2; -.
DR Proteomes; UP000000442; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR001261; ArgE/DapE_CS.
DR InterPro; IPR002933; Peptidase_M20.
DR PANTHER; PTHR43808; ACETYLORNITHINE DEACETYLASE; 1.
DR PANTHER; PTHR43808:SF8; M20_DIMER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01546; Peptidase_M20; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00758; ARGE_DAPE_CPG2_1; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000000442};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT REGION 433..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 55384 MW; B1B9D234149C4613 CRC64;
MPARPSSPMI PLHGTALMGF PTIIRGSDVN NSTNLSPLTM AAAEFTMDQR DFEIYLECLR
RVVGFPTLFT RPDQIEMAMA WCETFFASNL RDYRSYRDRN SNLIVCPLNL DPDQDVIYLS
AHMDTVDADA SEWDKPFLPF SLYEDAQQMV ARGVSDCKAG IAFELFLARL AGMGKMKLSN
LIFTITFKEE GPGMKSACAI GENFGHALPV SRQDTFFIVL ENTMTVANPS IFSFYTAERG
NFVIRVSDKI DRLQRILDHL AHWNPVSIRP DLEGPGSDCR IATQKGGHVC SVPRGQNILT
RIIEQARAND LVWAGDESNF SVVPPKIYTG RSERPATHHL VISNRSFDTI EDVHAQLKGI
TYTEVKDFSI SQGMNFDDVF SSHRLSRILK ASQVPGLNIC QTYNIGASDA TIVTRCMAPE
FKKRFYPIVM GPGTRSQRDK IPPRLTHGKN ETFDKKSGEA GVEFLLSVLT ALSCVDSKQW
DEDSRGVKTP SHLRF
//
