ID C0QRF2_PERMH Unreviewed; 388 AA.
AC C0QRF2;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Acriflavin resistance protein AcrE {ECO:0000313|EMBL:ACO03098.1};
GN OrderedLocusNames=PERMA_1480 {ECO:0000313|EMBL:ACO03098.1};
OS Persephonella marina (strain DSM 14350 / EX-H1).
OC Bacteria; Aquificota; Aquificae; Aquificales; Hydrogenothermaceae;
OC Persephonella.
OX NCBI_TaxID=123214 {ECO:0000313|EMBL:ACO03098.1, ECO:0000313|Proteomes:UP000001366};
RN [1] {ECO:0000313|EMBL:ACO03098.1, ECO:0000313|Proteomes:UP000001366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14350 / EX-H1 {ECO:0000313|Proteomes:UP000001366};
RX PubMed=19136599; DOI=10.1128/JB.01645-08;
RA Reysenbach A.L., Hamamura N., Podar M., Griffiths E., Ferreira S.,
RA Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A.,
RA Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.;
RT "Complete and draft genome sequences of six members of the Aquificales.";
RL J. Bacteriol. 191:1992-1993(2009).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP001230; ACO03098.1; -; Genomic_DNA.
DR RefSeq; WP_012675337.1; NC_012440.1.
DR AlphaFoldDB; C0QRF2; -.
DR STRING; 123214.PERMA_1480; -.
DR PaxDb; 123214-PERMA_1480; -.
DR KEGG; pmx:PERMA_1480; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_1_4_0; -.
DR OrthoDB; 9777308at2; -.
DR Proteomes; UP000001366; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 2.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF15; HLYD FAMILY OF SECRETION PROTEINS; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001366};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..298
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 103..130
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 388 AA; 43116 MW; 17A8FE3F82C2E385 CRC64;
MAGLIRFTLF FLLPVFVLIL WMGGYLTPRV EPGYAETEAK AVTGIKTAVI KPTVMKSEYE
VDGTVTSNNN AKVSTKLMAK ILDIKVKEGD TVKKGQLIAV LDDSEIKQNI REAKAALEEL
SKAREEALAG REAAKAGYEF AKRTYERFMN LYKDNAISKQ QLEEIETKMI GAKAQLDMID
AKLKQIDAKE KQVKAKLKYA RIMQSYAYVK APFDGVVIKK MNDIGDMAAP GMPIVIIGDK
DLRFLAQIDE KLIDKIHIGD EIDVYIETIG KKLKGTVVEK SKSVDPMNRS FTVKIKIPYI
KGVTPGMYGK IKIPVKSEEK ILIPESAVVK WGQLKAVYTV DKNGILHLTF VKLGDRINGK
YEVVSGIDAG TEIVVENTEK ACDGCKIR
//
