ID C0RW38_DANRE Unreviewed; 1126 AA.
AC C0RW38;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|RuleBase:RU362096};
DE EC=2.7.10.2 {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|RuleBase:RU362096};
GN Name=jak2b {ECO:0000313|EMBL:ABD73285.1,
GN ECO:0000313|RefSeq:NP_571162.1, ECO:0000313|ZFIN:ZDB-GENE-980526-123};
GN Synonyms=jak2 {ECO:0000313|RefSeq:NP_571162.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ABD73285.1};
RN [1] {ECO:0000313|RefSeq:NP_571162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_571162.1};
RX PubMed=12354655;
RA Van de Peer Y., Frickey T., Taylor J., Meyer A.;
RT "Dealing with saturation at the amino acid level: a case study based on
RT anciently duplicated zebrafish genes.";
RL Gene 295:205-211(2002).
RN [2] {ECO:0000313|RefSeq:NP_571162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_571162.1};
RX PubMed=16109975;
RA Woods I.G., Wilson C., Friedlander B., Chang P., Reyes D.K., Nix R.,
RA Kelly P.D., Chu F., Postlethwait J.H., Talbot W.S.;
RT "The zebrafish gene map defines ancestral vertebrate chromosomes.";
RL Genome Res. 15:1307-1314(2005).
RN [3] {ECO:0000313|RefSeq:NP_571162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_571162.1};
RX PubMed=16448862; DOI=10.1016/j.modgep.2005.10.005;
RA Tallafuss A., Hale L.A., Yan Y.L., Dudley L., Eisen J.S.,
RA Postlethwait J.H.;
RT "Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg
RT during zebrafish development.";
RL Gene Expr. Patterns 6:556-565(2006).
RN [4] {ECO:0000313|EMBL:ABD73285.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|EMBL:ABD73285.1};
RA Zhang J., Handin R.I.;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|RefSeq:NP_571162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_571162.1};
RX PubMed=18039395;
RA Stein C., Caccamo M., Laird G., Leptin M.;
RT "Conservation and divergence of gene families encoding components of innate
RT immune response systems in zebrafish.";
RL Genome Biol. 8:R251-R251(2007).
RN [6] {ECO:0000313|RefSeq:NP_571162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_571162.1};
RX PubMed=21048110; DOI=10.4049/jimmunol.1000549;
RA Aggad D., Stein C., Sieger D., Mazel M., Boudinot P., Herbomel P.,
RA Levraud J.P., Lutfalla G., Leptin M.;
RT "In vivo analysis of Ifn-gamma1 and Ifn-gamma2 signaling in zebrafish.";
RL J. Immunol. 185:6774-6782(2010).
RN [7] {ECO:0000313|RefSeq:NP_571162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_571162.1};
RX PubMed=23300608;
RA Yin J., Shine L., Raycroft F., Deeti S., Reynolds A., Ackerman K.M.,
RA Glaviano A., O'Farrell S., O'Leary O., Kilty C., Kennedy C., McLoughlin S.,
RA Rice M., Russell E., Higgins D.G., Hyde D.R., Kennedy B.N.;
RT "Inhibition of the Pim1 oncogene results in diminished visual function.";
RL PLoS ONE 7:e52177-e52177(2012).
RN [8] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [9] {ECO:0000313|RefSeq:NP_571162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_571162.1};
RX PubMed=25603810; DOI=10.1186/1752-0509-8-s5-s6;
RA Lin C., Lin C.N., Wang Y.C., Liu F.Y., Chien Y.W., Chuang Y.J., Lan C.Y.,
RA Hsieh W.P., Chen B.S.;
RT "Robustness analysis on interspecies interaction network for iron and
RT glucose competition between Candida albicans and zebrafish during
RT infection.";
RL BMC Syst. Biol. 8:S6-S6(2014).
RN [10] {ECO:0000313|RefSeq:NP_571162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_571162.1};
RX PubMed=24683187;
RA Briolat V., Jouneau L., Carvalho R., Palha N., Langevin C., Herbomel P.,
RA Schwartz O., Spaink H.P., Levraud J.P., Boudinot P.;
RT "Contrasted innate responses to two viruses in zebrafish: insights into the
RT ancestral repertoire of vertebrate IFN-stimulated genes.";
RL J. Immunol. 192:4328-4341(2014).
RN [11] {ECO:0000313|RefSeq:NP_571162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_571162.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [12] {ECO:0000313|RefSeq:NP_571162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_571162.1};
RX PubMed=29087020;
RA Zhang C.N., Zhang J.L., Huang Y., Ren H.T., Guan S.H., Zeng Q.H.;
RT "Dibutyltin depressed immune functions via NF-kappaB, and JAK/STAT
RT signaling pathways in zebrafish (Danio rerio).";
RL Environ. Toxicol. 33:104-111(2018).
RN [13] {ECO:0000313|RefSeq:NP_571162.1}
RP IDENTIFICATION.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_571162.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149,
CC ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|RuleBase:RU362096};
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004184}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. JAK subfamily. {ECO:0000256|PIRNR:PIRNR000636}.
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DR EMBL; DQ408763; ABD73285.1; -; mRNA.
DR RefSeq; NP_571162.1; NM_131087.1.
DR GeneID; 30298; -.
DR KEGG; dre:30298; -.
DR AGR; ZFIN:ZDB-GENE-980526-123; -.
DR CTD; 30298; -.
DR ZFIN; ZDB-GENE-980526-123; jak2b.
DR OrthoDB; 1614410at2759; -.
DR PhylomeDB; C0RW38; -.
DR Proteomes; UP000000437; Chromosome 5.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005131; F:growth hormone receptor binding; IBA:GO_Central.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0060397; P:growth hormone receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:UniProt.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13333; FERM_C_JAK2; 1.
DR CDD; cd10379; SH2_Jak2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR041155; FERM_F1.
DR InterPro; IPR041046; FERM_F2.
DR InterPro; IPR041381; JAK1-3/TYK2_PHL_dom.
DR InterPro; IPR037838; JAK2_FERM_C-lobe.
DR InterPro; IPR035860; JAK2_SH2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
DR PANTHER; PTHR45807; TYROSINE-PROTEIN KINASE HOPSCOTCH; 1.
DR PANTHER; PTHR45807:SF1; TYROSINE-PROTEIN KINASE JAK2; 1.
DR Pfam; PF18379; FERM_F1; 1.
DR Pfam; PF18377; FERM_F2; 1.
DR Pfam; PF17887; Jak1_Phl; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR Pfam; PF00017; SH2; 1.
DR PIRSF; PIRSF000636; TyrPK_Jak; 1.
DR PRINTS; PR01823; JANUSKINASE.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00219; TyrKc; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|PIRSR:PIRSR000636-
KW 2}; Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000636};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000636,
KW ECO:0000256|PIRSR:PIRSR000636-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000636};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|PIRNR:PIRNR000636}.
FT DOMAIN 28..364
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 383..468
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 528..794
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 834..1111
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 961
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000636-1"
FT BINDING 840..848
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000636-2"
FT BINDING 867
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000636-2"
FT BINDING 868
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1126 AA; 129538 MW; EE5610F4E957F2F5 CRC64;
MDMETAVCEP HYQNGDVHHE DPCPKQPTVL KIHLYHSSRS DADSSPICYP PGEYITEQLI
IHAAKESGVS PVYCSLFGLY KEDEAVWLSP NHVLHLDETA NESLLFRMRY YFPGWYSCGT
SRAYRYGVTK GSDSPVLDDY VMSYLFAQWR SDFVNGWVKL SGSHENQEEC LGMAVLDMMR
TAKEKDCSPL DIYNDISYKS FLPKDMRERI QDYHFVTRKR IRYRFRKVVQ QLSQCRVTAR
DLKLKYLISL ESLDNGFYTE RFQVKEPSTE QVTIVVSADR GIQWCHERHK DTQSEDLLQT
YCDFAEVVDI SIRQASKDGT NMNRIVSIDR QDGTPLELVF STSMQALSFV SLIDGYYRLT
TDAHHYLCKD VAPPYLLEAI ESYCHGPISM DFAISKLRKS GNQKGLFVLR CSPKDYNKYF
LTLAFGGYGN VEYKHCLITR SESGNYNLSG TKKSFRSLQD LLKCYQKETV KSDGIVFQFS
KCCSPRPKEK SSLLVCRSHR GLEVPLSSSL QRHNISQMVF HKIKKEDLEL GESQGQGTFT
KIFKGIRKEQ GDYGETHKTE VIVKVLDKAH RNYSESFFEA ASMMSQLTHK HLVLTYGICV
CGDENIMVQE YVKFGSLDTY LKKNKSSVSV NILWKLEVAK QLAWAMLYLE EKSLAHGNVC
AKNILLIREE DRALGNTPFI KLSDPGISIT VLPREILVER IPWVPPECIL DPKNLSLATD
KWSFGTTLWE ICSGGEQPLA NMDNSKKHLF YENHHQLPAP KWTELANLIN SCMDYEPTFR
PSFKAIIRDL NSLFCPDYEI VKESDIMPSR AAASIFNTGT FKNNEPVQFE ERHLIFLQQL
GKGNFGSVEM CRYDPLQDNT GEVVAVKKLQ HSTTEHIRDF EREIEILKSL QHENIVKYKG
VCYGAGRRNL RLVMEYLPYG SLRDYLNKNR DRIDHQKLVH YASQICKGME YLATKRYIHR
DLATRNILVE SECRVKIGDF GLTKVLPQDK EYYKVKEPGE SPIFWHAPES LTESKFSVAS
DVWSFGVVLY ELFTYSDKLC SPPTVFLSMV GGDKQGQTIV YHLIELLKRG NRLPQPMGCP
TEMFEIMQEC WDNDPSLRPN FKELALRVDL IRDSSDADRY TQVPEF
//
