ID   C0ZMU6_RHOE4            Unreviewed;       359 AA.
AC   C0ZMU6;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Putative zinc-containing alcohol dehydrogenase {ECO:0000313|EMBL:BAH35354.1};
DE            EC=1.1.1.- {ECO:0000313|EMBL:BAH35354.1};
GN   OrderedLocusNames=RER_46460 {ECO:0000313|EMBL:BAH35354.1};
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Rhodococcus; Rhodococcus erythropolis group.
OX   NCBI_TaxID=234621 {ECO:0000313|EMBL:BAH35354.1, ECO:0000313|Proteomes:UP000002204};
RN   [1] {ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT   PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BAH35354.1, ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RX   PubMed=16423019; DOI=10.1111/j.1462-2920.2005.00899.x;
RA   Sekine M., Tanikawa S., Omata S., Saito M., Fujisawa T., Tsukatani N.,
RA   Tajima T., Sekigawa T., Kosugi H., Matsuo Y., Nishiko R., Imamura K.,
RA   Ito M., Narita H., Tago S., Fujita N., Harayama S.;
RT   "Sequence analysis of three plasmids harboured in Rhodococcus erythropolis
RT   strain PR4.";
RL   Environ. Microbiol. 8:334-346(2006).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; AP008957; BAH35354.1; -; Genomic_DNA.
DR   RefSeq; WP_020908806.1; NC_012490.1.
DR   AlphaFoldDB; C0ZMU6; -.
DR   KEGG; rer:RER_46460; -.
DR   PATRIC; fig|234621.6.peg.5199; -.
DR   eggNOG; COG1063; Bacteria.
DR   HOGENOM; CLU_026673_11_1_11; -.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43189:SF1; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1198.01; 1.
DR   PANTHER; PTHR43189; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1198.01-RELATED; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:BAH35354.1}; Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          9..351
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   359 AA;  37837 MW;  AC9DE2E4920306AD CRC64;
     MRAVRFHQGE FAVAEMADAP PLAPHQIRID VVACGICGSD LSMSKDPCRF VEVAHNGGYP
     LATFDPDAPV VLGHEYAGIV AETGSAVDDF MIGDRVAGIG LATDTATGIP TIIGYSNEYH
     GAFGDHIVVD AFWVRKVPDH LSLEHATLAE PLHVGEMHLQ QSGLTSADSA LVVGCGTIGL
     GAIVAAKARG ARIVIASEPS PKRRELAKKM GADIVVDPFT QDPIELWNQM VAEGNPLVGQ
     AANGILIAYE CSGRAGVIGE LMRTLPFNSR IQVLAAPFGD ETVVPVIGQF RRISINFGHG
     PYENAYDITL ARLAAGEIDA EAIITGRVGL DGVSDAFAAL RAPDEHVKIL VLPAAGRPE
//