ID   C1A2A6_RHOE4            Unreviewed;       597 AA.
AC   C1A2A6;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=Probable long-chain fatty-acid--CoA ligase {ECO:0000313|EMBL:BAH34741.1};
DE            EC=6.2.1.3 {ECO:0000313|EMBL:BAH34741.1};
GN   Name=fadD {ECO:0000313|EMBL:BAH34741.1};
GN   OrderedLocusNames=RER_40330 {ECO:0000313|EMBL:BAH34741.1};
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Rhodococcus; Rhodococcus erythropolis group.
OX   NCBI_TaxID=234621 {ECO:0000313|EMBL:BAH34741.1, ECO:0000313|Proteomes:UP000002204};
RN   [1] {ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT   PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BAH34741.1, ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RX   PubMed=16423019; DOI=10.1111/j.1462-2920.2005.00899.x;
RA   Sekine M., Tanikawa S., Omata S., Saito M., Fujisawa T., Tsukatani N.,
RA   Tajima T., Sekigawa T., Kosugi H., Matsuo Y., Nishiko R., Imamura K.,
RA   Ito M., Narita H., Tago S., Fujita N., Harayama S.;
RT   "Sequence analysis of three plasmids harboured in Rhodococcus erythropolis
RT   strain PR4.";
RL   Environ. Microbiol. 8:334-346(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC         CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC         ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00024484};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422;
CC         Evidence={ECO:0000256|ARBA:ARBA00024484};
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DR   EMBL; AP008957; BAH34741.1; -; Genomic_DNA.
DR   RefSeq; WP_020908378.1; NC_012490.1.
DR   AlphaFoldDB; C1A2A6; -.
DR   KEGG; rer:RER_40330; -.
DR   PATRIC; fig|234621.6.peg.4566; -.
DR   eggNOG; COG1022; Bacteria.
DR   HOGENOM; CLU_000022_45_5_11; -.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:UniProtKB-EC.
DR   CDD; cd05907; VL_LC_FACS_like; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43272:SF32; AMP-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:BAH34741.1}.
FT   DOMAIN          24..423
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   597 AA;  63925 MW;  C5A7532F336DABEB CRC64;
     MSEYSAKAQF TISDNESVVH TVFTHAERTP ELTVFSRPKG EGWVDVTAKE FSEQVTGVAN
     GLIAAGVQAG DRVALLSATR YEWTLFDFAI WAAGAATVPI YDSSSQGQVS WILEDSEAVI
     AIVETGAHEQ LFQDAPSTLK AVMQIDDGAV EKLTAQGADV DDTELKKRLA GIKADDLASL
     VYTSGTTGRP KGCILTHRNF LSEVRGILTA SIGKVAVPGN RVLTFLPLAH VLARAVSLAT
     FEAGASQAHW SDFATITTQF ERYKPNTILG VPRVFEKVRD GAARKAESGG KMPGAIFAFA
     EATAKEYSQA LDKGGPSLIL KAKHAVADKL VYSKLRAALG GECWFAISGG GALTPELGHF
     FRGLGVPIYE GYGLTETTAA HCVNVPGAQK IGTVGQPMGG NGVRIAEDGE IELNGGVVFK
     GYWKNDKATE ETFVNGWMRT GDLGELDSDG YLSITGRKKD LLVTAGGKNV SPGPMEDRIR
     SHSIVSQAVV VGDGKTYITA LLTVDPEVFE KWKSENGKPS GATVAELRDD KDLRAELQKA
     VDDANAAVSH AESIKKFVIL DRDLTEEDGE MTATLKIKRN VVVDRFSKEI EGMYAKS
//