ID   C1AAG4_GEMAT            Unreviewed;      1105 AA.
AC   C1AAG4;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   OrderedLocusNames=GAU_2720 {ECO:0000313|EMBL:BAH39762.1};
OS   Gemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC
OS   100505).
OC   Bacteria; Gemmatimonadota; Gemmatimonadetes; Gemmatimonadales;
OC   Gemmatimonadaceae; Gemmatimonas.
OX   NCBI_TaxID=379066 {ECO:0000313|EMBL:BAH39762.1, ECO:0000313|Proteomes:UP000002209};
RN   [1] {ECO:0000313|Proteomes:UP000002209}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T-27 / DSM 14586 / JCM 11422 / NBRC 100505
RC   {ECO:0000313|Proteomes:UP000002209};
RA   Takasaki K., Ichikawa N., Miura H., Matsushita S., Watanabe Y., Oguchi A.,
RA   Ankai A., Yashiro I., Takahashi M., Terui Y., Fukui S., Yokoyama H.,
RA   Tanikawa S., Hanada S., Kamagata Y., Fujita N.;
RT   "Complete genome sequence of Gemmatimonas aurantiaca T-27 that represents a
RT   novel phylum Gemmatimonadetes.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP009153; BAH39762.1; -; Genomic_DNA.
DR   RefSeq; WP_015894531.1; NC_012489.1.
DR   AlphaFoldDB; C1AAG4; -.
DR   STRING; 379066.GAU_2720; -.
DR   REBASE; 20597; GauT27ORF2720P.
DR   KEGG; gau:GAU_2720; -.
DR   eggNOG; COG0827; Bacteria.
DR   eggNOG; COG1002; Bacteria.
DR   HOGENOM; CLU_282518_0_0_0; -.
DR   OrthoDB; 9761012at2; -.
DR   Proteomes; UP000002209; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002209};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          341..476
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   1105 AA;  122100 MW;  95846616D0235BA4 CRC64;
     MLTLRAAAQL LSRADSHSAL RALAPVLGFA PDPLTVPTAI RRDLGLQDLV QRADLFEGPG
     ALRLLTAHLT PADTLDGAHD LRERTKRVAE ALVRHAPTRQ WLLCTIDDQE CMLCLAAVSD
     TNGGPRVAAL RVDRRRVLDS DADTFRALAA AAHDPSPIRH ARFTDILRRD ALSLRFYRAL
     EQAVDTLARS LAPSGRTRSR AATALTPAQR RELALLCLSR CLFLGFLEAK GWLDDRRDFL
     LHHTLRVLES GGALHERLLR PLFFGTLNTP RRARAVTARL FGRVPFLNGG LFSPTALERR
     ARTLHFSDDA LTALITGVLD RYRFTAHEDS TSWSEAAVDP EMLGRAFESL MAAEDRRRSG
     AFYTPPHLVD AAISEALTAL LPSIPAAVLE ESSNAPLSAE AAFTITHRLA CLRVLDPACG
     SGAFLVRALE RFDTLLKRAG DQRPAHERRR ALLTLGIFGV DRDPMAVWLC ELRLWLAVVI
     ECHDPDIDRI APLPNLDHHI RIGDSLAGGT FRFAPPSGRT LSTLRARYSR ASGARKITIA
     SALDQEERRR SVAELSSRLD AIGRERRQLL TSLRGRDLFG QRTRATRADR ARLTTLRTST
     RELSTHRKRL QLGGALPFRF GAMFADVGAA HGFDLVVGNP PWVRPHAMPE HERQWLRQEF
     RAMRHAGWRA GATRAGAGAG FAAQADLAVA FVERSMQLLA PRGTLALLVP AKLWRTLAGG
     GIRRALQQEM HLHALHDWSD APAQFDAATY PSLVVATRRA SPAAADTSRF AESSPLLLKD
     SPVRVTIVRE TPLHFQVEPH ALSLDGDPDA PWLLLPHAPR LAFQRLRDAG PPLAHSPLGR
     PLLGVKCGCN AAFLVHAHEH DDHSATVTAL TTSAPRQGVI ERHLLRPALR GEAVRDPFAP
     KVDDREEPPH ANDLRIIWTH GLDGAALPTL PTATQRWLAH WRPRLHARRD ARHHTPWWSL
     FRTDSARNDA PRVVWADIGR SLRTQVLPAG DPTVPLNSCY VVRVPTDSDA FALHALLQST
     VSAAWLDPLA EPARGGFRRF LGWTIASLPL PADWPAARRI LAPIGERLHR GISPPTRDTL
     DAAVTDTYGL TFDQIQPLID WYRRG
//