ID ILVD_STRP7 Reviewed; 567 AA.
AC C1CAX1;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 29-MAY-2013, entry version 34.
DE RecName: Full=Dihydroxy-acid dehydratase;
DE Short=DAD;
DE EC=4.2.1.9;
GN Name=ilvD; OrderedLocusNames=SP70585_2252;
OS Streptococcus pneumoniae (strain 70585).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=488221;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70585;
RA Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.;
RT "Complete genome sequence of Streptococcus pneumoniae strain 70585.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-
CC oxobutanoate + H(2)O.
CC -!- COFACTOR: Binds 1 4Fe-4S cluster (Potential).
CC -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC isoleucine from 2-oxobutanoate: step 3/4.
CC -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC from pyruvate: step 3/4.
CC -!- SIMILARITY: Belongs to the IlvD/Edd family.
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DR EMBL; CP000918; ACO17641.1; -; Genomic_DNA.
DR RefSeq; YP_002741409.1; NC_012468.1.
DR ProteinModelPortal; C1CAX1; -.
DR STRING; 488221.SP70585_2252; -.
DR EnsemblBacteria; ACO17641; ACO17641; SP70585_2252.
DR GeneID; 7683192; -.
DR KEGG; snm:SP70585_2252; -.
DR PATRIC; 19670944; VBIStrPne83895_2281.
DR eggNOG; COG0129; -.
DR HOGENOM; HOG000173155; -.
DR KO; K01687; -.
DR OMA; NMPGAMI; -.
DR ProtClustDB; PRK00911; -.
DR BioCyc; SPNE488221:GH4U-2206-MONOMER; -.
DR UniPathway; UPA00047; UER00057.
DR UniPathway; UPA00049; UER00061.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:HAMAP.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009097; P:isoleucine biosynthetic process; IEA:HAMAP.
DR GO; GO:0009099; P:valine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00012; IlvD; 1; -.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR004404; DihydroxyA_deHydtase.
DR InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR PANTHER; PTHR21000; PTHR21000; 1.
DR Pfam; PF00920; ILVD_EDD; 1.
DR SUPFAM; SSF52016; Aconitase/3IPM_dehydase_swvl; 1.
DR TIGRFAMs; TIGR00110; ilvD; 1.
DR PROSITE; PS00886; ILVD_EDD_1; 1.
DR PROSITE; PS00887; ILVD_EDD_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Amino-acid biosynthesis;
KW Branched-chain amino acid biosynthesis; Complete proteome; Iron;
KW Iron-sulfur; Lyase; Metal-binding.
FT CHAIN 1 567 Dihydroxy-acid dehydratase.
FT /FTId=PRO_1000116528.
FT METAL 125 125 Iron-sulfur (4Fe-4S) (Potential).
FT METAL 197 197 Iron-sulfur (4Fe-4S) (Potential).
SQ SEQUENCE 567 AA; 59859 MW; 6B1EB36C02F2BB02 CRC64;
MTELDKRHRS SIYDSMVKSP NRAMLRATGM TDKDFETSIV GVISTWAENT PCNIHLHDFG
KLAKEGVKSA GAWPVQFGTI TVADGIAMGT PGMRFSLTSR DIIADSIEAA MSGHNVDAFV
AIGGCDKNMP GSMIAIANMD IPAIFAYGGT IAPGNLDGKD IDLVSVFEGI GKWNHGDMTA
EDVKRLECNA CPGPGGCGGM YTANTMATAI EVLGMSLPGS SSHPAESADK KEDIEAAGRA
VVKMLELGLK PSDILTREAF EDAITVTMAL GGSTNATLHL LAIAHAANVD LSLEDFNTIQ
ERVPHLADLK PSGQYVFQDL YEVGGVPAVM KYLLANGFLH GDRITCTGKT VAENLADFAD
LTPGQKVIMP LENPKRADGP LIILNGNLAP DGAVAKVSGV KVRRHVGPAK VFDSEEDAIQ
AVLTDEIVDG DVVVVRFVGP KGGPGMPEML SLSSMIVGKG QGDKVALLTD GRFSGGTYGL
VVGHIAPEAQ DGGPIAYLRT GDIVTVDQDT KEISMAVSEE ELEKRKAETT LPPLYSRGVL
GKYAHIVSSA SRGAVTDFWN MDKSGKK
//
