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Database: UniProt
Entry: C1CAX1
LinkDB: C1CAX1
Original site: C1CAX1 
ID   ILVD_STRP7              Reviewed;         567 AA.
AC   C1CAX1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   14-MAY-2014, entry version 38.
DE   RecName: Full=Dihydroxy-acid dehydratase;
DE            Short=DAD;
DE            EC=4.2.1.9;
GN   Name=ilvD; OrderedLocusNames=SP70585_2252;
OS   Streptococcus pneumoniae (strain 70585).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=488221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70585;
RA   Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.;
RT   "Complete genome sequence of Streptococcus pneumoniae strain 70585.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-
CC       oxobutanoate + H(2)O.
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster (Potential).
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 3/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC       from pyruvate: step 3/4.
CC   -!- SIMILARITY: Belongs to the IlvD/Edd family.
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DR   EMBL; CP000918; ACO17641.1; -; Genomic_DNA.
DR   RefSeq; YP_002741409.1; NC_012468.1.
DR   ProteinModelPortal; C1CAX1; -.
DR   STRING; 488221.SP70585_2252; -.
DR   EnsemblBacteria; ACO17641; ACO17641; SP70585_2252.
DR   GeneID; 7683192; -.
DR   KEGG; snm:SP70585_2252; -.
DR   PATRIC; 19670944; VBIStrPne83895_2281.
DR   eggNOG; COG0129; -.
DR   HOGENOM; HOG000173155; -.
DR   KO; K01687; -.
DR   OMA; TPMEFNT; -.
DR   OrthoDB; EOG6MSS24; -.
DR   BioCyc; SPNE488221:GH4U-2206-MONOMER; -.
DR   UniPathway; UPA00047; UER00057.
DR   UniPathway; UPA00049; UER00061.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009099; P:valine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00012; IlvD; 1.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR004404; DihydroxyA_deHydtase.
DR   InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR   InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR   PANTHER; PTHR21000; PTHR21000; 1.
DR   Pfam; PF00920; ILVD_EDD; 1.
DR   SUPFAM; SSF52016; SSF52016; 1.
DR   TIGRFAMs; TIGR00110; ilvD; 1.
DR   PROSITE; PS00886; ILVD_EDD_1; 1.
DR   PROSITE; PS00887; ILVD_EDD_2; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Amino-acid biosynthesis;
KW   Branched-chain amino acid biosynthesis; Complete proteome; Iron;
KW   Iron-sulfur; Lyase; Metal-binding.
FT   CHAIN         1    567       Dihydroxy-acid dehydratase.
FT                                /FTId=PRO_1000116528.
FT   METAL       125    125       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       197    197       Iron-sulfur (4Fe-4S) (Potential).
SQ   SEQUENCE   567 AA;  59859 MW;  6B1EB36C02F2BB02 CRC64;
     MTELDKRHRS SIYDSMVKSP NRAMLRATGM TDKDFETSIV GVISTWAENT PCNIHLHDFG
     KLAKEGVKSA GAWPVQFGTI TVADGIAMGT PGMRFSLTSR DIIADSIEAA MSGHNVDAFV
     AIGGCDKNMP GSMIAIANMD IPAIFAYGGT IAPGNLDGKD IDLVSVFEGI GKWNHGDMTA
     EDVKRLECNA CPGPGGCGGM YTANTMATAI EVLGMSLPGS SSHPAESADK KEDIEAAGRA
     VVKMLELGLK PSDILTREAF EDAITVTMAL GGSTNATLHL LAIAHAANVD LSLEDFNTIQ
     ERVPHLADLK PSGQYVFQDL YEVGGVPAVM KYLLANGFLH GDRITCTGKT VAENLADFAD
     LTPGQKVIMP LENPKRADGP LIILNGNLAP DGAVAKVSGV KVRRHVGPAK VFDSEEDAIQ
     AVLTDEIVDG DVVVVRFVGP KGGPGMPEML SLSSMIVGKG QGDKVALLTD GRFSGGTYGL
     VVGHIAPEAQ DGGPIAYLRT GDIVTVDQDT KEISMAVSEE ELEKRKAETT LPPLYSRGVL
     GKYAHIVSSA SRGAVTDFWN MDKSGKK
//
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