GenomeNet

Database: UniProt
Entry: C1CNE9
LinkDB: C1CNE9
Original site: C1CNE9 
ID   DLTA_STRZP              Reviewed;         516 AA.
AC   C1CNE9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-SEP-2014, entry version 41.
DE   RecName: Full=D-alanine--poly(phosphoribitol) ligase subunit 1;
DE            EC=6.1.1.13;
DE   AltName: Full=D-alanine-D-alanyl carrier protein ligase;
DE            Short=DCL;
DE   AltName: Full=D-alanine-activating enzyme;
DE            Short=DAE;
GN   Name=dltA; OrderedLocusNames=SPP_2228;
OS   Streptococcus pneumoniae (strain P1031).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=488223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P1031;
RA   Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.;
RT   "Complete genome sequence of Streptococcus pneumoniae strain P1031.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the biosynthesis of D-alanyl-lipoteichoic
CC       acid (LTA). Catalyzes an ATP-dependent two-step reaction where it
CC       forms a high energy D-alanyl AMP intermediate and transfers the
CC       alanyl residues from AMP to Dcp (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + D-alanine + poly(ribitol phosphate) =
CC       AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate).
CC   -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme
CC       family. DltA subfamily.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000920; ACO21603.1; -; Genomic_DNA.
DR   RefSeq; YP_002739255.1; NC_012467.1.
DR   ProteinModelPortal; C1CNE9; -.
DR   STRING; 488223.SPP_2228; -.
DR   EnsemblBacteria; ACO21603; ACO21603; SPP_2228.
DR   GeneID; 7682790; -.
DR   KEGG; spp:SPP_2228; -.
DR   PATRIC; 32461838; VBIStrPne91701_2262.
DR   eggNOG; COG1020; -.
DR   HOGENOM; HOG000229995; -.
DR   KO; K03367; -.
DR   OMA; IAINDFP; -.
DR   OrthoDB; EOG6QP0WP; -.
DR   BioCyc; SPNE488223:GHE7-2185-MONOMER; -.
DR   UniPathway; UPA00556; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0047473; F:D-alanine-poly(phosphoribitol) ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070395; P:lipoteichoic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00593; DltA; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR010072; DltA.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 1.
DR   TIGRFAMs; TIGR01734; D-ala-DACP-lig; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding.
FT   CHAIN         1    516       D-alanine--poly(phosphoribitol) ligase
FT                                subunit 1.
FT                                /FTId=PRO_1000146976.
SQ   SEQUENCE   516 AA;  57427 MW;  C20C9E7F8EB7150B CRC64;
     MSNKPIADMI ETIEHFAQTQ PSYPVYNVLG QEHTYGDLKA DSDSLAAVID QLGLPEKSPV
     VVFGGQEYEM LATFVALTKS GHAYIPIDSH SALERVSAIL EVAEPSLIIA ISAFPLEQVS
     TPMINLAQVQ EAFAQGNNYE ITHPVKGDDN YYIIFTSGTT GKPKGVQISH DNLLSFTNWM
     ITDKEFATPS RPQMLAQPPY SFDLSVMYWA PTLALGGTLF TLPSVITQDF KQLFAAIFSL
     PIAIWTSTPS FADMAMLSEY FNSEKMPGIT HFYFDGEELT VKTAQKLRER FPNARIINAY
     GPTEATVALS AVAVTDEMLA TLKRLPIGYT KADSPTFIID EEGNKLPNGE QGEIIVSGPA
     VSKGYMNNPE KTAEAFFEFE DLPAYHTGDV GTMTDEGLLL YGGRMDFQIK FNGYRIELED
     VSQNLNKSRF IESAVAVPRY NKDHKVQNLL AYVILKDGVR EQFERDIDIT KAIKEDLTDI
     MMSYMMPSKF LYRDSLPLTP NGKIDIKGLI NEVNKR
//
DBGET integrated database retrieval system