ID C1EBU4_MICCC Unreviewed; 1187 AA.
AC C1EBU4;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=Transient receptor potential Ca2+ channel family {ECO:0000313|EMBL:ACO65474.1};
GN ORFNames=MICPUN_61192 {ECO:0000313|EMBL:ACO65474.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO65474.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO65474.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001329; ACO65474.1; -; Genomic_DNA.
DR RefSeq; XP_002504216.1; XM_002504170.1.
DR AlphaFoldDB; C1EBU4; -.
DR STRING; 296587.C1EBU4; -.
DR GeneID; 8246389; -.
DR KEGG; mis:MICPUN_61192; -.
DR eggNOG; KOG1328; Eukaryota.
DR eggNOG; KOG3676; Eukaryota.
DR InParanoid; C1EBU4; -.
DR OrthoDB; 1003028at2759; -.
DR Proteomes; UP000002009; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00030; C2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR PANTHER; PTHR10582:SF2; INACTIVE; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50004; C2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:ACO65474.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 341..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 972..991
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1012..1035
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1079..1104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 130..162
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 173..199
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 623..756
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1187 AA; 129696 MW; 4C0220AFB3ECB468 CRC64;
MPKKRGGDDV VRSDDAVAEQ ARSFDTPGTP WYAVKHGTLE DLMDIWPATR CARPHHAGVT
ADDPCELCGC RADVFDTGAV GENILHICVL FHTTETLRMA RYLVLKFGAA LVNAPYQQRR
RVTDPPGLYE GETALHIAIV HRDAELVSFL LNHGARLDVH AIGTFFAPGR VYFGETPLAF
AASTGATELV DILLKHAFDR GGKKLRDAVL NDADALGNTA AHMAVVNNRL DCYDHLVDQC
GASESVENNA GLTPFLIAAR DGNAHAFNRV LRRKFAAVWR FGPVTSYNLN LTGIDTVGAR
ASDRPENAVD VLVRSHRIEL LSHPVLVAVL DLKWRRFAKA AFLRHLACYA AFLALFAWLV
AEHVGRRERS EWRSGRRIAA EWCCFAGVAA MSYLHVRDLR FYARKYYRSL TVRNGKSSDV
PTYSLPGRGV DGRCNPRQRP VQVRWVGRGT RIGRDWTQGR GGPVPEPSDS TVVATVSTTS
IDEEADFAAT DADTKTPPGS PPPNSSKTLR KQDSTRSIGR FRAFDAGQGG TGAESGDSAR
RKARRRGGFF GRMLSGSGGI VHSRSSNHFL FDSLGSTGCG GGGDDDGFAF GGVVDVRSAI
ARGRWRLLRE RWMERNWPGV ARKRLGLSHS LSRADDFDDR VVVLLRVNVL GARGLPAADA
NGASDPYCVV HAAPGVIART QPVMETLEPL WHRSFSFTAP PGLRRSGNCV FLSVIDYDGY
DEADEDGDDR LGFAAVPHHD VQYVGSGIAA PGPTWLDLMP TRREAESRAL EHSRRSRAAE
SAAVAEGTPS SSPSSRPVGQ ILAEVYYEVV NKSKGGVHTD FYPRDEAAID GNNQRRLVGP
QPPLRKRLGA LGYEVVGGDA RAVLTGKTSD KNVADGFPFG EDGDGDGFGS DSGEEGEGEA
ETTVAEAVAE VRRAIKNSKR GARHAFLAIK CWITSVFVPQ PLMWLNLAHL ILHAFHFVDW
NLSEAPSARD DVVFSLAALA AWGFFMYFVA TSRRVGFFVV IVARCIKDVV KFSALWIIAM
LAFSQAFYIL GAGWLGDPAL KPASFGAVAW KLFAVATAAE GFFDDVMPDT DVSSGGVEFT
YTALVVAYQV LMSVLMLNVI IAMFNQTFSR VSDRSRDEWT LQWALKVLLA EARLEPVERF
RHRLGAEVDG PGSERAQNFE INFAEGMQEK GSVEAAIREL LSEDPKR
//
