ID C1EBU5_MICCC Unreviewed; 725 AA.
AC C1EBU5;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=MICPUN_102212 {ECO:0000313|EMBL:ACO65783.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO65783.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO65783.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- SIMILARITY: Belongs to the SARM1 family.
CC {ECO:0000256|ARBA:ARBA00008291}.
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DR EMBL; CP001329; ACO65783.1; -; Genomic_DNA.
DR RefSeq; XP_002504525.1; XM_002504479.1.
DR AlphaFoldDB; C1EBU5; -.
DR STRING; 296587.C1EBU5; -.
DR GeneID; 8246082; -.
DR KEGG; mis:MICPUN_102212; -.
DR eggNOG; ENOG502QWGM; Eukaryota.
DR InParanoid; C1EBU5; -.
DR OMA; SDAIIMC; -.
DR OrthoDB; 312677at2759; -.
DR Proteomes; UP000002009; Chromosome 9.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0019677; P:NAD catabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09487; SAM_superfamily; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR46270; ARMADILLO-TYPE FOLD-RELATED; 1.
DR PANTHER; PTHR46270:SF2; TIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunity {ECO:0000256|ARBA:ARBA00022588};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009}.
FT DOMAIN 642..719
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
SQ SEQUENCE 725 AA; 79480 MW; 4645936ACF69E85D CRC64;
MRTARRCQYS RSAIRASRGS ASRRSVAVNV AAEPAKAIEP APAPNLLQRE QYPPHLRWPE
TLYDEARVGG KKEFDARLAD ASAVIHAWAE AVEGGECDTV SEEASEAADW IRQALTMKIE
LGDKDLAVKQ SKAAGNSGEN QSDLVLMAQY GSVHALLALQ AMCHKNSVVC GRLVKGDDVF
KIVKETLEHS PYDQVRCAAM SLASSILGFN EETHKIAAKN TMGVLVTQEL ARWCNVDDDG
NATCNFEVGF RDLRGMDTCD HASVALRYLS ANAANHNMLK KMGCVELLLN LMAARPDSSV
RINAAVCVAD IVGRDEMDSR IQSDPTIVEE TLSALEAILD GNAADSGITF EAHELIQGLA
NLANVDATKR RFADAGAVPL ITRALLEPQY KWDLVMLHSS AAIWNLAFDE SIREEIKACP
GALDGLEEAN KVGSEMTKAK ARGALWMINS DAEEAVDHKI SEDKVKLLTS GGSTAATQVM
LSYEWHSQAQ AKALRDELVE EGFTVWMDVD RMMGSTLEAM AAAIESSDAI IMCVTNRYRE
SQACRTEAEY AYTRKKLMIP AMLQKNYKPD GWLGILMGSK LYYNMHNQED IRNAMPAIKA
EVAKSMGEKK AIGGEIDGAN GAAQATPNLS SQAASKEIKV PDNKDTMTLW LENHGLGQYS
AAFKKEHMYG KALLKLHEEI GHGDPEKATY HDLFQSVLGI TSYGHRLLFL AELEELIGPI
KWKRR
//
