ID C1EDY1_MICCC Unreviewed; 716 AA.
AC C1EDY1;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=NADP dependent malic enzyme, chloroplast {ECO:0000313|EMBL:ACO66442.1};
GN ORFNames=MICPUN_62430 {ECO:0000313|EMBL:ACO66442.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO66442.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO66442.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785}.
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DR EMBL; CP001330; ACO66442.1; -; Genomic_DNA.
DR RefSeq; XP_002505184.1; XM_002505138.1.
DR AlphaFoldDB; C1EDY1; -.
DR STRING; 296587.C1EDY1; -.
DR GeneID; 8247606; -.
DR KEGG; mis:MICPUN_62430; -.
DR eggNOG; KOG1257; Eukaryota.
DR InParanoid; C1EDY1; -.
DR OMA; MVYAACG; -.
DR OrthoDB; 1069499at2759; -.
DR Proteomes; UP000002009; Chromosome 11.
DR GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006108; P:malate metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23406:SF79; MALATE DEHYDROGENASE (OXALOACETATE-DECARBOXYLATING); 1.
DR PANTHER; PTHR23406; MALIC ENZYME-RELATED; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PRINTS; PR00072; MALOXRDTASE.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002009}.
FT DOMAIN 211..391
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 402..658
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 74251 MW; 423BDFDBE787A934 CRC64;
MTSALTCATA SRPVTRAGPR PRSTRADARH PRVVNARARS TSAPGDAIGR DVVPEPASSE
TIEGIVVDDD RDGSPVRISG NVRASRRGVL GGLGGVGAAL GLTSSTSAIV GPGAAEAAAA
PASSPAPIAE IAAASSRATS ASPASSIVGY ANLHDPRVFN GLATPDRTNR SLDGLIPAGE
APPDVEVARA AAALEACDTP MQKYRQLVSL QNTDETTFYA LLELKTAELL PVLYTPTVGD
ACLQFGTLTQ RPPGLYVSLE NIGNVRALVD NWPANDVRIA VLTDGERILG LGDQGVNGMG
ISAGKSMVYA ACGIKPGWLL PVQVDNGTNN TKLLADPLYV GTRRERVRGE AYDRLLDETV
QAIQGRYGAR TVIHWEDFAP RNAFRNLQRF RTKGAITYND DIQGTAAVTV AGILASLRVT
KRALREQRVL FFGAGQANIG AAELLVRALT EEGVDESLAR SNVFLFDSKG LVVDGRPAEY
TISDDKAPFA AKVGTPFTSS LEEAVKSVRP TALVGAAAQP QVFTKRVIES MCAFNPRPVI
FALSNPTSKA ECTATQAYEW SKGKAVFASG TLFAPVNYKG VRFAPGFANN AFIFPGVALG
SLASGASSVT DAMFLAAARS LASQVSEENL AVGAVYPPTS TIREAAVVVG AAVAAAADEG
GVAAPGACRG GAIPGRDGGR SVVVPSLDAL TGGGNPGDGT CANWEACVRD YLKTCV
//
