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Database: UniProt
Entry: C1F915_ACIC5
LinkDB: C1F915_ACIC5
Original site: C1F915_ACIC5 
ID   C1F915_ACIC5            Unreviewed;      1189 AA.
AC   C1F915;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   24-JAN-2024, entry version 93.
DE   RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE            Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE            EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN   Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN   ECO:0000313|EMBL:ACO34679.1};
GN   OrderedLocusNames=ACP_2078 {ECO:0000313|EMBL:ACO34679.1};
OS   Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM
OS   7670 / NBRC 15755 / NCIMB 13165 / 161).
OC   Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC   Acidobacterium.
OX   NCBI_TaxID=240015 {ECO:0000313|EMBL:ACO34679.1, ECO:0000313|Proteomes:UP000002207};
RN   [1] {ECO:0000313|EMBL:ACO34679.1, ECO:0000313|Proteomes:UP000002207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 /
RC   NCIMB 13165 / 161 {ECO:0000313|Proteomes:UP000002207};
RX   PubMed=19201974; DOI=10.1128/AEM.02294-08;
RA   Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA   Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA   Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA   Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA   Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA   Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA   Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA   Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT   "Three genomes from the phylum Acidobacteria provide insight into the
RT   lifestyles of these microorganisms in soils.";
RL   Appl. Environ. Microbiol. 75:2046-2056(2009).
CC   -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC       polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC       release of RNAP and its truncated transcript from the DNA, and
CC       recruitment of nucleotide excision repair machinery to the damaged
CC       site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC       RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR   EMBL; CP001472; ACO34679.1; -; Genomic_DNA.
DR   RefSeq; WP_015897179.1; NC_012483.1.
DR   AlphaFoldDB; C1F915; -.
DR   STRING; 240015.ACP_2078; -.
DR   KEGG; aca:ACP_2078; -.
DR   eggNOG; COG1197; Bacteria.
DR   HOGENOM; CLU_005122_1_3_0; -.
DR   InParanoid; C1F915; -.
DR   OMA; WAPPCRE; -.
DR   OrthoDB; 9804325at2; -.
DR   Proteomes; UP000002207; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR   CDD; cd17991; DEXHc_TRCF; 1.
DR   Gene3D; 2.40.10.170; -; 1.
DR   Gene3D; 3.40.50.11180; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR   Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR   HAMAP; MF_00969; TRCF; 1.
DR   InterPro; IPR003711; CarD-like/TRCF_RID.
DR   InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR004576; Mfd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047112; RecG/Mfd.
DR   InterPro; IPR037235; TRCF-like_C_D7.
DR   InterPro; IPR005118; TRCF_C.
DR   InterPro; IPR041471; UvrB_inter.
DR   NCBIfam; TIGR00580; mfd; 1.
DR   PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR   Pfam; PF02559; CarD_TRCF_RID; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF03461; TRCF; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM01058; CarD_TRCF; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00982; TRCF; 1.
DR   SUPFAM; SSF141259; CarD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR   SUPFAM; SSF143517; TRCF domain-like; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00969};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00969};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000002207}.
FT   DOMAIN          654..815
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          835..990
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1189 AA;  132867 MW;  9A50C736EB965693 CRC64;
     MILPFVRDLL ADLEHTASFE QAQRHLSLSR GRRRVSGLTS TARSLYIPLL ARAAKVPVVL
     LVADNKAADA MHLALRAGCE LTGAIAAERV LKLPAHDVLP FENMSPHPEV QEQRATTLWK
     IATGDAAIVI APVEAAAMKL FPAPFYGGLA QVLRRGEEID VDMLLTHLAS VGYEQVDVVE
     MPGQYTRRGG ILDVYSPEAD RPVRMEFFGD EIETMRKFDP ESQRSQSPLD EARLLPLTET
     PVTERLLAAV HARLSGARFE TNDEGEMVAE MVAAGGVSVF PGWEFFAGVA GANKTLLDLF
     PRCVLFVEEP GMIKNQVERW WNKVEQRHDR SSIGTLIRPE DIYLRPELLE AQRKSHPGLD
     IDQLGAVDVL EDDETLGEIA FSSRPTLRFH GSIPAFVEQI KNLMQQETRM LLAAPNQGEV
     ERLATLLREY ELPYRLGSRV MHTGSETMYD EASHLGGDLR TPIILRAPIA TGVSLPDANL
     VVFGANDLND EADVTARPAA RKSKTAAFIS DFRDLAVGDY VVHVEHGIAR YLGLKEIAQD
     GTTLEFMILE FAEEAKLYVP LTRLDLIQKY RSTESGPAPV LHRLGTQQWA KTKARVKKAM
     QDMADELLKL YAQRKAAQGH AYSADNEFQR EFEDSFDYNE TDDQLSAIAD IKRDMESTTP
     MDRLLCGDVG YGKTEVAMRA AFKAVQDGKQ VAVLTPTTVL SFQHYETFKK RFRQFPIHIE
     MLSRFRTAKE QKLIVERVEA GEIDILIGTH RLLSKDLKFH DIGLLIVDEE QRFGVRHKER
     LKQLRAQLDV LTMSATPIPR TLHMSLVGLR DMSVIETPPK DRMAIQTIVA KFDEKLVRSA
     VEVELERGGQ IYFVHNRVET IYEIAAKIQE LVPHARITVG HGQMGEAELE KVMLAFMNHE
     YDVLVATSII ENGLDIPLAN TILINRADRH GLSELYQLRG RVGRSNRRAY AYLMIPPEQE
     LTEIARRRLA ALKEFSDLGA GFKIAALDLE LRGAGNMLGG EQSGHIEAVG FELYTTMLEE
     AVNKMKGQET VERPVTQLSL GIPLRIDDSY IPEENQRLRM YKHIAGAQDE RAIAGIRAEL
     VDRYGALPTG VRHLLDAAEL RIACEHMGVA QVDRKRDQIH LKFTEKASID PGILMKLVSK
     NAKRGAQFTP QGVLRFPLSG TDPESIFTEL RVLLDDLATQ PAAARQGAS
//
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