ID C1FFM0_MICCC Unreviewed; 771 AA.
AC C1FFM0;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=DNA mismatch repair protein-MLH2/PMS1/Pms2 family {ECO:0000313|EMBL:ACO69396.1};
DE Flags: Fragment;
GN Name=Pms1 {ECO:0000313|EMBL:ACO69396.1};
GN ORFNames=MICPUN_65816 {ECO:0000313|EMBL:ACO69396.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO69396.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO69396.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CP001575; ACO69396.1; -; Genomic_DNA.
DR RefSeq; XP_002508138.1; XM_002508092.1.
DR AlphaFoldDB; C1FFM0; -.
DR STRING; 296587.C1FFM0; -.
DR GeneID; 8245484; -.
DR KEGG; mis:MICPUN_65816; -.
DR eggNOG; KOG1978; Eukaryota.
DR InParanoid; C1FFM0; -.
DR OMA; RMRIIGQ; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000002009; Chromosome 8.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009}.
FT DOMAIN 219..340
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 562..734
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 379..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACO69396.1"
FT NON_TER 771
FT /evidence="ECO:0000313|EMBL:ACO69396.1"
SQ SEQUENCE 771 AA; 83174 MW; 68557BB8D0224D43 CRC64;
GPDDPAPSTA LQKEAPSIRP IGASSVHRIC SGQVVLDLAG AVKELVENAL DAGATNIEVR
LRDHGQDSVE VVDNGCGVKS DDLAMMTKKY ATSKIRRFED LDALASFGFR GEALSSLCAL
SDLSVTTRTA DSDAGTRVEY DAEGNVRTRG VVARAVGTTV TVQNVFARLP VRRKELARNV
KREYGKLLNI LQAYALINPE TRIVCSHQGK GKNAPRQTVL NTQGGGSLRA AVATVFGHKT
IDGMVSKAAP GCGRGAGDRQ FFFVNGRPVD LPKAARVCNE TYRQYNQTTS GTPFPCVVLD
FRLPTDAYDV NVTPDKRKVL LHGESKVLAG LRGALEKIWS PTAYTYAVAA AGAADGSETT
RVRVHDAIGA ARDVIAGGPS AATPALPPAS AVGVKREREE DDDATVVAPS VDVKREPAED
RVPRGTSAAA SAWESFGMNA PRHNTANDAT TTANDRVGTG KVGRTRRTFP CTVRQSTRPR
RSASSRGPRA RLSRTRTTSH RAATHREARV KRRREGTRGA SVNDRATAEG GLGPALNEGG
DEVATGELER VFRREDFRDM RVVGQFNLGF ILCTLGDDLF IVDQHASDEI YNFERLQRTT
TLNRQPLLVP KKLELTAAET QTVHRNMPTF LANGFGFCEV DQPPPTVRSL ALNSVPFSKG
ITFGADDVHE LIGMLDQGEY ALPARSQLTV GLSRQSTGTP GSGLSVSEIV RPSRVRAMLA
MRACRSSIMI GKALDAKTMR RVLDNLSDLQ APWNCPHGRP TMRHLADLRK L
//
