ID C1FXX5_DASNO Unreviewed; 568 AA.
AC C1FXX5;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 22-FEB-2023, entry version 46.
DE RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
GN Name=AD_m008_jsm2898Fr {ECO:0000313|EMBL:ACO83099.1};
OS Dasypus novemcinctus (Nine-banded armadillo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Xenarthra; Cingulata; Dasypodidae; Dasypus.
OX NCBI_TaxID=9361 {ECO:0000313|EMBL:ACO83099.1};
RN [1] {ECO:0000313|EMBL:ACO83099.1}
RP NUCLEOTIDE SEQUENCE.
RA Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C.,
RA Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M.,
RA Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N.,
RA Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B.,
RA Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R.,
RA Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C.,
RA Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C.,
RA Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K.,
RA Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J.,
RA Tsipouri V., Young A., Green E.D.;
RT "NISC Comparative Sequencing Initiative.";
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC {ECO:0000256|RuleBase:RU368069}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC ECO:0000256|RuleBase:RU368069}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DP001090; ACO83099.1; -; Genomic_DNA.
DR RefSeq; XP_004453042.1; XM_004452985.1.
DR AlphaFoldDB; C1FXX5; -.
DR GeneID; 101436384; -.
DR KEGG; dnm:101436384; -.
DR CTD; 8131; -.
DR HOGENOM; CLU_014030_1_0_1; -.
DR OrthoDB; 8983at2759; -.
DR GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR005365; Npr3.
DR PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR Pfam; PF03666; NPR3; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|RuleBase:RU368069};
KW Signal {ECO:0000256|RuleBase:RU368069}.
FT REGION 28..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 62920 MW; 1632C603446919A4 CRC64;
MGDNTSPISV ILVSSGSRGN KLLFRYPFQR SQEHPASQTN KPRSRYAVHS TGDHSDDQDG
DSRFSDVILA TILATKSEMC GQKFELKIDN VRFVGHPTLL QHALGQVSKT DPSPKRETPT
MILFNVVFAL RANADPSVIS CLHSLSRRIA VVLQHEERRC QYLTREAKLI LALQDEVSAV
ADADEGPQSP FHHILPKCKL ARDLKEVHDS LCASGVVRLH INNWLEVSFC LPHKSHHLAS
SLSPPEAIER SLKAIRPYHA LLLLGDEKSL LDELPVDCSP ALVRVVKTAS AVKNLQQLAQ
DADLALLQVF QLAAHLVYWG KAIIIYPLCE NNVYMLSPSA SLCVYSPLAE QFSRQFPAHD
LPSVLAKFSL PVSLSEFKNP LAPPVQETQL VQMVVWLLQR RVLVQLHTYV CLMAAPSEEA
RARDEDAPLA ARVGGRSLST PNALSFGSPT SSDDMTLTSP SMDNSSAELL PGGDSPLSRR
MTESLLASLS EHERAAILSV PAAQNPEDLR TFARLLHYFR GRHHLEEIMF NENTRRSQLL
TLLDKFRSVL VVATHEDPVI AVFQAQPK
//
