ID   C1FZM4_PARBD            Unreviewed;       917 AA.
AC   C1FZM4;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 2.
DT   24-JAN-2024, entry version 59.
DE   RecName: Full=PX domain-containing protein {ECO:0000259|PROSITE:PS50195};
GN   ORFNames=PADG_00064 {ECO:0000313|EMBL:EEH43775.2};
OS   Paracoccidioides brasiliensis (strain Pb18).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH43775.2, ECO:0000313|Proteomes:UP000001628};
RN   [1] {ECO:0000313|EMBL:EEH43775.2, ECO:0000313|Proteomes:UP000001628}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pb18 {ECO:0000313|EMBL:EEH43775.2,
RC   ECO:0000313|Proteomes:UP000001628};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
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DR   EMBL; KN275957; EEH43775.2; -; Genomic_DNA.
DR   RefSeq; XP_010755677.1; XM_010757375.1.
DR   AlphaFoldDB; C1FZM4; -.
DR   STRING; 502780.C1FZM4; -.
DR   GeneID; 22579960; -.
DR   KEGG; pbn:PADG_00064; -.
DR   VEuPathDB; FungiDB:PADG_00064; -.
DR   eggNOG; KOG2273; Eukaryota.
DR   HOGENOM; CLU_007739_1_1_1; -.
DR   InParanoid; C1FZM4; -.
DR   OMA; KWHSDKT; -.
DR   OrthoDB; 1449900at2759; -.
DR   Proteomes; UP000001628; Unassembled WGS sequence.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06869; PX_UP2_fungi; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR024554; DUF3818_PX-associated.
DR   InterPro; IPR024555; PX-associated.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR047168; YPR097W-like.
DR   PANTHER; PTHR47185; PX DOMAIN-CONTAINING PROTEIN YPR097W; 1.
DR   PANTHER; PTHR47185:SF1; PX DOMAIN-CONTAINING PROTEIN YPR097W; 1.
DR   Pfam; PF12825; DUF3818; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF12828; PXB; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50195; PX; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001628}.
FT   DOMAIN          193..373
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          263..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          805..834
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   917 AA;  104789 MW;  1BC0967E8ED43087 CRC64;
     MENGTGNSAN AGSTPPAHPT PAQGLILTGK QEHYLKRELI SLQVRGEIAE LNSPTALRRF
     GAPFKSEFGE IRPIDSELPI LRFIFVHHVR NFPFLDKAKE KEFWQDKLQT FLESFANKHI
     SSSEDRYEET KRRKLAQKCE KLVELMMVSG IPTASGYEER IRFSEMEVVD RGANEQGLLV
     NIPEGHAIHG WDVNVAGART TLVKRTVRYH QHAEFILRVR RHGRPDRYVG RRFGEFVKLH
     KRLHTEMPGK ILPPVPRKNK NFVSSTLLSG GDDDASSVSS NSTHDVNFVD DTRSSRNLNV
     KQDQQKRSSS RSSFNRTPKV PRSSGELVTE PVMLFREEQR VSLRAFLRTL LQNPRIAESK
     AMEEFLTADP ITLNEEELTD IQRRKDLDAK RIEEQRQFYE IARKRAQELD VYMEQFRQDI
     VENNGLTKLF QEIRAKRSVE ELSPQYQKFA EWLRIEVAAT VYHLFLAEDN SPELFAQAKR
     IHSLIPYTLM KNVIRIANPA AVMSGVLDLF LAQPFGSRSL LQRIFSLAIH DGIKTLQRTI
     DGLSSKVDDP ILVNKLRAFT EADEVVKDEI RSEAKDDDVD IVVAILRSEL IEPELNPGQI
     EKVFNSYVAW INTVENVDLE MHQGAQWFAY LKQLLKMVTR QRDKAMMLSI IEEPVTLQLF
     RDLFTIFYEP LVRVYKSANV YNSITDFAEF ADDAIAVIER AHRQDVSADP NQTVQSFIDL
     CARHQHSFYK FVHEVHLHDN GLFDALMAWL EDILHFLRHG PQTGGKLDMN ALFKGAVDVG
     QIDPEVAIRE IDSLVKWHAE RKKWHHDKTR QKMAAEGSGV GASSDSGLPG STTFRGSDFG
     LDEADLDDLA IDDITSNTSD EDSADDDMDP IALERKRRAK LQDRLRRTAG EPVKPDIKEI
     LKLRESFGAM LRMVLDD
//