ID C1FZR2_PARBD Unreviewed; 2086 AA.
AC C1FZR2;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=PADG_00102 {ECO:0000313|EMBL:EEH43813.1};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH43813.1, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:EEH43813.1, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:EEH43813.1,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; KN275957; EEH43813.1; -; Genomic_DNA.
DR RefSeq; XP_010756201.1; XM_010757899.1.
DR STRING; 502780.C1FZR2; -.
DR GeneID; 22579993; -.
DR KEGG; pbn:PADG_00102; -.
DR VEuPathDB; FungiDB:PADG_00102; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_2_1; -.
DR InParanoid; C1FZR2; -.
DR OMA; WQYVPVR; -.
DR OrthoDB; 1818010at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 1.
DR CDD; cd19542; CT_NRPS-like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001628}.
FT DOMAIN 855..930
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1512..1588
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2086 AA; 231198 MW; 113813B84D5063B1 CRC64;
MYSDGRPEVT NQRKDTIIKV ELGCNCDKIP RWQNVKLLGV GECLVWRNRP AQTLCIPWDD
KVITYSSNSK KAPARTTTGC QLQESIVLDC TMNSNLSPGE DVKTNGGVHL NGDADGRVDA
ISIEQPLFLN RNMEDQLDLL VLAWVLLLYR GSGLSEDGEF AWGLTEASND EFSNFRPKFS
GNIIDIISGE SDHISKPLES IRARRPSISN DERKQLKDYS IFFTNVAHTA EKYGDLAFAV
EISVSGEKLY LQHHGQHSTL SRNAIEIHVD GFIDIFNSIV VNLDMTVAQA MQIGDRELQQ
LWKWNAIVPP EIDECIHVTF MKNAQKNSNR MAVVSWDGEL SYGEVDRFST QLAIRLIELG
VKIGTAVPLC FEKSMWTVVA VLAVMKAGGA LVLTDPGQPE ARLETIVTEV SANLMLTSVK
QEELGHRLLP RGTVLAVSHH IFQSEQNSCF TAALPSVPGS STLYIIFTSG STGKPKGVVI
SHANYVSGAL LRAEAVGYGP HSRVLDFPSY AFDVSIDCML CTLAHGGCVC VPSEDDRVNN
LSGAIRNMKV NMAHMTPSVA RVLESDILPS LEVLGLGGES VSARDAANWG RFTKIIIAYG
PSECTVGCTI NNDVHIDRSY TSIGKGVGGV TWVVDPADHN RLMPIGAIGE LIIEGPIVGQ
GYLNDPVKSS TVFIKDPTWL VSGGGGIPGR HGRFYKTGDL VRYGPDGSGS IVFVGRGDQQ
VKLRGQRVEL GEVEHHLRMK LPAGTTVAAE VITPGGMKGE PTLVAFIAQE NTPKARGQGE
IAAFSTELQH VLNIMDKELA ASLPRYMVPA AYIPLFEMPL LVSCKTDRKK LRAIGSAMSR
KELIKLRTST EQAREPQSEM ERKLQHIMID LFGKEADINV QSNFFDLGGD SLMAMKLVAA
ARRENILTSV ADIFRYPTLS ELALTLKHTD DVDVHTEVPP FSLIDSTWQA EDARVEAANL
CSLNASSIVD MYPCTPLQEG LMALSAKISE AYVAQRVVEL KDIQTAERLQ RAFETAVADS
AILRTRIVQV PGHGLMQVVV RDEISWRSGR TLEEYLAQDR NEPMGLGTEL VRFAVLPNKK
TNGAHFVLTI HHALYDGWSM PLIVRRINRA YNGKEIERPV SFNSFIKYLS GLNSNESKSY
WKAQLQGATS LQFPSLPWPG YQTQPQSLLE HYVPISKPLI SSTSIAIAIR AAWGLVAGAY
TASDDVIFGE TLTGRNASVV GVDKIEGPMI TTVPVRVRID RNSRVSEYLR KIQDDTAFRI
PHEHMGLQHI RRLSPDAREA CELRTGIVIH PMATEDDTSI TGEGPANGFV PAGDEDAARE
ALKFNTYALM LVCSLDPKGF LVMASFDSAT IDVTQMDKVL GQFGRTVQRL FDDSGELVSN
LQLMSEEDLA EVWHFSNTSK YLDEGVLGAN CSGATATWVV DPQNPERLLP FGAIGELLIE
GQFKSATSTS IQSTNWLAAG CRDMPGRRGK LHETSQLVKY NSDGSLVFKG QKSDVIKSNI
ETEKREVKKR LHATTSEQQK LQELWSRILG INKEEVDLND NFFDLGGDSI SAMKLVSEGR
MEGLELTVMQ VFQHRRLSDM ADIVKDSLSL STPAKAYVPF STLDISDIET FISESIRPAL
ADPSWIIADI LPARPLQEIA VDGTTKLPRY SARYELFYLD AAVDRPHLFK SCQELISRNE
ILRTVFVKSR GSCFGVVLQD LQLPLVEYEI DGDLETFAEQ LCNLDVQMVM PLGSPFIKFL
FVRCSDGRSC LIMRISHAQY DEICLPILLR QLSALYERRS LPSALPFSSF VHHVVRENIP
KSIQYWRDLL KGASMSILRP STPLESKKSV FICKTFDISS RPKDITIATL PSAAWALCLA
RRLAVRDVTF GEVVSGRNID LPNCDTVMGP TWQYVPVRIK FEPGWTGVDL LNFVQHQHIS
STRFEGIGLK EIVKHCTDWS ETVDWFDSVV HQDVEHVESL AFLSANSRMD TIYPHLEPLR
EWKIQAFPKG DSLGIEIVTF ESWRAEANSI LNELGDIISQ LLTKRNSALF WTDKTSSNPR
PRCSGAYFDA SRDICRNYNM LEKISSRQVS SSVAEGERLW SAENRF
//
