ID   C1FZR6_PARBD            Unreviewed;       706 AA.
AC   C1FZR6;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PADG_00106 {ECO:0000313|EMBL:EEH43817.1};
OS   Paracoccidioides brasiliensis (strain Pb18).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH43817.1, ECO:0000313|Proteomes:UP000001628};
RN   [1] {ECO:0000313|EMBL:EEH43817.1, ECO:0000313|Proteomes:UP000001628}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pb18 {ECO:0000313|EMBL:EEH43817.1,
RC   ECO:0000313|Proteomes:UP000001628};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
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DR   EMBL; KN275957; EEH43817.1; -; Genomic_DNA.
DR   RefSeq; XP_010756204.1; XM_010757902.1.
DR   AlphaFoldDB; C1FZR6; -.
DR   STRING; 502780.C1FZR6; -.
DR   GeneID; 22579997; -.
DR   KEGG; pbn:PADG_00106; -.
DR   VEuPathDB; FungiDB:PADG_00106; -.
DR   eggNOG; KOG2645; Eukaryota.
DR   HOGENOM; CLU_017594_4_0_1; -.
DR   InParanoid; C1FZR6; -.
DR   OMA; DGHKFGP; -.
DR   OrthoDB; 1366859at2759; -.
DR   Proteomes; UP000001628; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd16018; Enpp; 1.
DR   Gene3D; 3.30.1360.180; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR002591; Phosphodiest/P_Trfase.
DR   PANTHER; PTHR10151:SF120; BIS(5'-ADENOSYL)-TRIPHOSPHATASE; 1.
DR   PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR   Pfam; PF01663; Phosphodiest; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001628};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        164..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          616..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        626..679
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   706 AA;  79813 MW;  14136168FEB22588 CRC64;
     MPLRKAPPCP SLLSPSAYDD DVSSLRSLSD QDSDSEDDEL VKDSRTTLEL SQHDRTVLEE
     EEERERLLVR QSRVDGLWRI LGSGHDNASS VRIGKRERKR QRCLQRRAER IKRQEGKENG
     QGLMYEMEEG KFHDDASSQS SAASSDLVPV TADSRFYTSS RGSWCWKICL LSNGVVVLFL
     LLLLGAYKES TGFRSSHRHR TILSNGTSLF APTTILISLD GFRADFLNRG LTPTLNSFIA
     NGISPDYMLP SFPSVTFPNH FTLVTGLYPE SHGIVGNTFW DPILKEEFHY SYPSRSMQPK
     WWTAEPLWVT AENQGVRTAI HMWPGSEAHV ANVEPTYLDK YNGKEDLLRK ANRVLSFLDL
     PGEEDDLPSN TNRRPQLIAA YVPNVDSDGH KFGPNSTEIR TTITNVDKML ANIFQGLHDR
     NLTEVVNLVI VSDHGMATTS TDRLVQLEDL IDMDLVDRID GWPLRGIRPK RPEDLETLKQ
     QLSKSSKAYH DSIEVYTRET MPERYHFSNN DRIAPLWVIP KTGWAIVERT EFDVKKMQMN
     KEVYRPRGLH GYDHEHPLMR SIFVARGPKF PHNPNSRMEV FQNIEVYNII CDSLEIKPFP
     NNGTLRLPLN PIGLHSDKNN PALETPEDPP VSTSSSASIT LTTQTSSQNL KPTSISASAV
     PTATSAPDND DGNDSTNESS SFWDRILNKL QRLSNWASMF LESVVE
//