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Database: UniProt
Entry: C1G0G7_PARBD
LinkDB: C1G0G7_PARBD
Original site: C1G0G7_PARBD 
ID   C1G0G7_PARBD            Unreviewed;      2374 AA.
AC   C1G0G7;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   22-JAN-2014, entry version 25.
DE   SubName: Full=Phosphatidylinositol 3-kinase tor2;
GN   ORFNames=PADG_00357;
OS   Paracoccidioides brasiliensis (strain Pb18).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; mitosporic Onygenales; Paracoccidioides.
OX   NCBI_TaxID=502780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pb18;
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A.,
RA   Goldberg J., Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M.,
RA   Grynberg M., Gujja S., Heiman D.I., Henn M.R., Kodira C.D.,
RA   Leon-Narvaez H., Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L.,
RA   Morais F.V., Pereira M., Rodriguez-Brito S., Sakthikumar S.,
RA   Salem-Izacc S.M., Sykes S.M., Teixeira M.M., Vallejo M.C.,
RA   Walter M.E., Yandava C., Young S., Zeng Q., Zucker J., Felipe M.S.,
RA   Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G., Puccia R.,
RA   San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- SIMILARITY: Contains FAT domain.
CC   -!- SIMILARITY: Contains FATC domain.
CC   -!- SIMILARITY: Contains PI3K/PI4K domain.
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DR   EMBL; DS572750; EEH44068.1; -; Genomic_DNA.
DR   OrthoDB; EOG7Z3FCR; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008144; F:drug binding; IEA:InterPro.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR   Gene3D; 1.10.1070.11; -; 3.
DR   Gene3D; 1.25.10.10; -; 6.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024585; DUF3385_TOR.
DR   InterPro; IPR003152; FATC.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR009076; Rapamycin-bd_dom.
DR   InterPro; IPR026683; TOR.
DR   PANTHER; PTHR11139:SF9; PTHR11139:SF9; 1.
DR   Pfam; PF11865; DUF3385; 1.
DR   Pfam; PF02259; FAT; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF08771; Rapamycin_bind; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF47212; SSF47212; 1.
DR   SUPFAM; SSF48371; SSF48371; 5.
DR   SUPFAM; SSF56112; SSF56112; 2.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   4: Predicted;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Transferase.
SQ   SEQUENCE   2374 AA;  268138 MW;  C9D4D05105E8BA2B CRC64;
     MAQVPSGTDA TQRIFHDLKS KHEETRSRAS FELHENVAVA SRELPPDKFI EYYNAVSQRI
     AQLVVTGNDV NEKIGGLLAL DRLIDFDGVD AAQKTTRFAS YLRSALRSND STVLVYAARS
     LGRLAKPGGA LTAELVESEI QSAMEWLQSE RQENRRFAAV LVIRELAKGS PTLLYGFVPQ
     IFELIWVALR DQKVLIRETS AQAVSECFEI LAARDFQVRQ QWFGRIYEEC LLGLRSSNVD
     WIHGSLLTLR ELLLKGAMFM NEHYRNACEI VLRLKDHREP KIRIQIVLTI PILASYAPLE
     FTNIYLHRFM IYLQAQLKRE KERNAAFIAI GKIANAVGNS IAQFLDGIIV YIREGLTLKA
     RNRAAVDEGP MFECISMLSL AVGQTLSKYM EALLDPIFAC GLSESLTQAL VDMAHYIPPI
     KATIQEKLLD MLSIVLCGTP FRPLGCPENR PPPMPSFAKD YGPFLQEPTD NEIALALHTL
     GSFDFSGHIL NEFVRDVAIT FVNNDNPEIR KASALTCCQL FVSDPILNQK SSHSIQVVGE
     VVDTLLTVGI GDPDPDIRRI VLESLDKKFD SHLAKPESVR CLFLAVNDEV FPVREAAISI
     IGRLSGVNPA YVFPPLRKLL VNLLTGLSFA TTSRQKEESA QLISLFVANA TKLVRSYVDP
     MVTALFPKTT DPNPGVAATT LKAIGELATV GGEDMRQYLP QLMPIILDAL QDLSCQSKRE
     AALRTLGQLA SNAGYVIEPY LEYPHLLAVL INIVKTEQTG SLRKETIKLL GIIGALDPYK
     HQQISESVPD IHHINEVQRV SDVSLIMQGL TPSNEEYYPT IVINTLLQNI LNESSLAQYH
     SAVIDAIVTI FKTLGLKCVP FLGQIIPAFV LVIRSTPTSR LESYFNQLAI LVTIVRQHIR
     AFLPEIIEVI REFWDSSYQV QATILSLIEA IAKSLEGEFK KYLAGLIPLM LDTLDKDITP
     RRQPSERILH TFLIFGSSGE EYMHLIAPAI VRLFDKTQSP SGIRKSAIET LGKLSRQVNV
     SDFSSLMIHP LSRVIAGTDR TLRQAALDCI CTLIFQLGQD FNNYIQLINK TISAHQISHH
     NYQILVSKLQ KGDPLPQDLN PDEHYSTLGD DSTFADVGQK KILVNQQHLK NAWDASQKST
     REDWQEWIRR FSVELLKESP SHALRACASL AGIYQPLAKD LFNAAFVSCW TELYGQYQEE
     LVRSIDMALT SQNIPPEILQ ILLNLAEFME HDDKALHIDI RTLGKYAGKC HAFAKALHYK
     ELEFEQDQNS GAVEALISIN NQLQQSDAAI GILRKAQAYR DVELKETWFV KLQRWEEALA
     AYKRRELIDP DSFDVTMGKM RCLHALGEWK MLSDLAQEKW NHASNEHRKA MAPLAAGAAW
     GRGQWELMDS YISVMKEQTP DRSFFGAILA IHNRKFDEAA MFIEKARNGL DTELSALLGE
     SYNRAYNVVV RVQMLAELEE IIIYKQSDDD PEKQEAMKET WNKRLLGCQQ NVEVWQRMLK
     VRALVISPRE NLDMWIKFAN LCRKSNRMGL ADRSLSSLEG GELGTPPEVA YARLKYEWAA
     GRQKEALQML RDFTIGLTEE FARYNAALVA HSEHAPADRP GLVNGISDHP ELALTRQHIG
     DVGKFRRLLA KSHLKQGEWQ TALQRGDWTS EGVRDVLNSY SAATQYNRDS YKAWHAWALA
     NFEVVNALST QTNRETVVPH HIVLEHVIPA IRGFFRSIAL SSTSSLQDTL RLLTLWFTHG
     GDAEVSGVVS EGFTSVIVDT WLEVTPQLIA RINQPNARVR GAVHRLLAEV GKAHPQALVY
     PLTVATMSNV VRRSQSASHI MDSMRQHSPR LVEQAEIVSH ELIRVAVLWH ELWHEGLEEA
     SRLYFGDHNV EGMFATLAPL HDMLDKGAET LREVSFAQAF GRDLAEAKHF CLLYRESGVI
     GDLNQAWDLY YTVFRKIARQ LPQLQSLDLK YVSPKLKDAV DLELAVPGTY QSGKPVIRIM
     SFDPVSIVLQ TKKRPRKMTL KGSDGNSYMY ALKGHEDIRQ DERVMQLFGL VNTLLDHDSE
     SFKRHLTIQR FPAIPLSQNS GLIGWVSNTD TLHALIKEYR ESRRILLNIE HRIMLQMAPD
     YDNLTLMQKV EVFGYAMDNT TGKDLYRVLW LKSKSSESWL ERRTNYTRSL GVMSMVGYIL
     GLGDRHPSNL LLERITGKIV HIDFGDCFEI AMHREKYPER VPFRLTRMLT FAMEVSNIEG
     SYHITCEAVM RVIRENKESL MAVLEAFIHD PLINWRLGAR ESPARPSFAA DRRQSVVEEI
     NMDHPMQPSN FSRRRPSILE GGILDAQQGV PNEAREVQNA RALQVLSRVK EKLTGRDFKS
     TEELNVSDQV DKLLVQATSV ENLCQHYIGW CSFW
//
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