ID   C1G671_PARBD            Unreviewed;       482 AA.
AC   C1G671;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=SH3 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PADG_02676 {ECO:0000313|EMBL:EEH46578.1};
OS   Paracoccidioides brasiliensis (strain Pb18).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH46578.1, ECO:0000313|Proteomes:UP000001628};
RN   [1] {ECO:0000313|EMBL:EEH46578.1, ECO:0000313|Proteomes:UP000001628}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pb18 {ECO:0000313|EMBL:EEH46578.1,
RC   ECO:0000313|Proteomes:UP000001628};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
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DR   EMBL; KN275959; EEH46578.1; -; Genomic_DNA.
DR   RefSeq; XP_010758562.1; XM_010760260.1.
DR   AlphaFoldDB; C1G671; -.
DR   STRING; 502780.C1G671; -.
DR   GeneID; 22582115; -.
DR   KEGG; pbn:PADG_02676; -.
DR   VEuPathDB; FungiDB:PADG_02676; -.
DR   eggNOG; KOG1843; Eukaryota.
DR   HOGENOM; CLU_025518_1_0_1; -.
DR   InParanoid; C1G671; -.
DR   OMA; MLAHYYT; -.
DR   OrthoDB; 2972088at2759; -.
DR   Proteomes; UP000001628; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0051666; P:actin cortical patch localization; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   CDD; cd07599; BAR_Rvs167p; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR046982; BIN3/RVS161-like.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR47174; BRIDGING INTEGRATOR 3; 1.
DR   PANTHER; PTHR47174:SF2; SH3 DOMAIN SIGNALLING PROTEIN (AFU_ORTHOLOGUE AFUA_5G07670); 1.
DR   Pfam; PF03114; BAR; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51021; BAR; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001628};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          6..241
FT                   /note="BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51021"
FT   DOMAIN          425..482
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          272..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..373
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   482 AA;  53835 MW;  865652F6220877A2 CRC64;
     MNSVHRQFGK FMKRSADDSH VSVLLKDFDD ADKLLARVID SCKAWRDAWM SILTYQSRLV
     QEFDSLYNPI VGSSEPSTSH SPVETPEVTL ARTSRLNEAY EELKTELLTE INSVDERMIK
     PAMNAKDYLQ PMKKIIKKRD DKKLDFERYQ NRVDTSRRKM KRSDRDNSAL AKAEIDLSRA
     KDEYNAADEH LRTHLPPLIT ATFSILPHLL AAQIDIQNNL LALYYTTLHN YCEQENFPSP
     PPPMDLIIQT WERDILPAQR EVESIGCVAY RRGSRQSRTS EEHRNGTYPN GLGSRRPSSQ
     SVICKSSASP ISNIRPPSPV FESKPRSNDH SPPSINAISF TKPRYSPPIS SGPPSEISDY
     STNTNTSAGV TPSGYTPAGP RMDYFSRERQ PSGAGGGSLG MTQMAAAAAK KKPPPPPPPP
     RAASSHAVFV TALYDFPGQG AGDLAFREGD RIRVLKKTDS TDDWWEGELK GMKGSFPANY
     CH
//