ID C1GEJ0_PARBD Unreviewed; 2821 AA.
AC C1GEJ0;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 06-MAR-2013, entry version 22.
DE SubName: Full=Ataxia telangiectasia mutated;
GN ORFNames=PADG_05676;
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; mitosporic Onygenales; Paracoccidioides.
OX NCBI_TaxID=502780;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18;
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Ma L.-J.J.,
RA Henn M.R., Champion M., Cuomo C., Jaffe D.B., Young S.K., Gnerre S.,
RA Berlin A., Heiman D., Hepburn T., Sykes S., Yandava C., Alvarado L.,
RA Kodira C.D., Guigo R., Borodovsky M., Goldman B., Klein B.,
RA Mendoza L., Nino-Vega G., San-Blas G., Sil A., de Almeida Soares C.M.,
RA Taylor J., Lander E.S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "Annotation of Paracoccidioides brasiliensis Pb18.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Contains 1 FAT domain.
CC -!- SIMILARITY: Contains 1 FATC domain.
CC -!- SIMILARITY: Contains 1 PI3K/PI4K domain.
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DR EMBL; DS572755; EEH49597.1; -; Genomic_DNA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0000077; P:DNA damage checkpoint; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016572; P:histone phosphorylation; IEA:InterPro.
DR GO; GO:0090399; P:replicative senescence; IEA:InterPro.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 1.10.1070.11; -; 3.
DR InterPro; IPR015519; ATM/Tel1.
DR InterPro; IPR003152; FATC.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR021668; TAN.
DR PANTHER; PTHR11139:SF3; PTHR11139:SF3; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF11640; TAN; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Kinase_like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW Transferase.
SQ SEQUENCE 2821 AA; 319169 MW; 6EE34C01ED95098D CRC64;
MKEVSLEDAL EAIRSDKQKD RTDGLEDLKH ILLQSRQTPK LNNLGDKNYH KIFEALFRFI
SIEKSFYKRT KSSISKSTSA SRLTSCASAL RTTVELGVQR IRLKTVTALL YHITDALPNP
EDALWEPLSG DYIKILRITL QYAPHVEHLS KDDWRHLIDF CLRAIGVIEP SQGHQLSIRS
RSRLPSESLD EPNSRANSVE PGSFRRSRNS RSDATGNNEE LETCIQLLCS CPISPVLDNA
GKLLNGLVDY LLSLNSISRA PYAAFRALNA VLSKSVTDDI TLVRDILLDV IPIIKRFWRT
KSAALRDEML ITLMLGRPVF LQIGLSYPPD SFVELLQGLL ERICQEYMRQ PEKDLMQVDD
LVFSFDPIPR PLGIRTMAPR LGVPRSEQNW TTLQVIANLS TLLDKLCHTL DENSQAVGRP
NKKLHLLSRL SDIVREASTS TGLARICALQ LLPFVLLDWE PGVDELLSTL EQLTVNILDE
NGSSASWTMI AIASIASCPA AMSPELRPLW TQVWDLASRT LASPTTSRAS CHLMTAILHF
KLLDYSSIVD TIELMTSSID LNGPAGLTDS ALLMWATMVE FRTKINPAQN QDMSKQICAW
IRNSYIGSPP SVGSSVRQHP NDQVVLELLQ TKIDSFNEIW TQLCNDKRQH VTVEIIQILV
SLCLTSTIFA ELLPIPVSFR CQSLQKSTEK LWTSFCGYFA KKEVEFLHAC LDILSPIILP
LKLSLDTKDP ILNAVHRMTP GLVSVFDHHR KAELDLSHST TEPMDLDIQF SSKESHTREN
DLTPKFDRED TPSYGDQNSI RRATATHLFI LHHFYEAKKN LEVPTNETLV SYITSLDEAD
ILTCRTNLAV LLGSWPNISR SDACILLEFF GEKCLQSYEL ERCEGTLSLC INLMISFVDL
WTAEEDDELF ESASDLYDWF TGVIVRKKLG SSRVLIRIAR LMESVLRTNP LFGRENSRLS
PRTSLFKILY DGDLTVKFHL SKIIPSVFDR FILKEYDVIF DDILESLPRD PDWNEGIALR
LYVLAQLASK WHTLLRRGIY HIFEAPGQLP KSSPYAKACL KEVANSLGLN NAKEIFKLFA
PQMIYTWLET ESLGSIPFTI FGYETFNELL IDVKDEVVAQ IVMRGKDDEM AGVSSYLSVP
FPELLEESFY KAEAYCIARD ISIPPSQDSQ PKGTESRIKK LLGPEKFVSL LERFFPETVA
VFFKCVDQTE QIERGFEKRP PFKFALDIWR DIGERSSSSA ALPASQQPSF RARYLLDEFE
FLCARSGYDL ETMWTPALVC FVARTLIESI HPSLGSLHAC SVIRKLKILI CIAGPVVLEE
YPLEMLLHFL RPFLSDFHCS GDAIGLFWYL IDKGRSYLLE NPSFMAGLGV STLVSLRGFL
SSSQKSTAQE THFHSSLSNA QMFYDWFAKF MNEYISPKLS RESEKSFRNL VGSSQRIQLA
GNASKGTYEG EFMAGLLQDS ASGKGLLSVP ATDLIFSLVC NDFQRPNNFR DDILGDDKIA
AENAITVWKS IQHQDHSSGY RLWAARALGR AYASTGVIDG SMLKETRSIS FDDIPECIRF
TSKFSIIRML CDSLFSNSRK DIGLAEQALQ TIFTRFPSDP NLGECAAAIP PSTMKALTWT
PYICPDLSLT ASQRTQFNHD IRWIPDVPVD EWARDVTLCL TNKEAADPIM GALPKVLFEI
PSLAVKLLPC VVHDVLVSEY EDRQSSRQAI SEVFRQAFRD VRETVFPHIR LIIHCILYLR
HQKIPHESTM NQRDAWLEID YLEAANAATQ CQMYKTALLF VEIHFSRTPS TRRSAISKSS
DSLLLLHDIF KSIEDPDLFY GIQQSATLDS VLEKVQHESA GLKNLTFQSA NYETDMKLFN
SIGEVNALGV IKALNSTNFQ GVASAMFAAP SGIGKRAEVF ESMLSTSLYL QQWDIPLPST
TASANGNVFK VLQSLNSSDN KMQVVRTLDD CFSEILSRLL EENQSKVELR TMMRALGVLT
EVDEVLSSQT PEDLQDEWER MLSRSSWLKF ESFCDVNLIL SSHEALFSSI KRKPHLRSML
GLSSRDAQLL EVKAIRESLK ISREHDEHQA SLKSAISLCK LIQPCADLGV FIDAAATFDL
ANVLWDQGEM TTSIQILQQL NEQKDLPKQS IPVNKAEVLA SLGHHVAEAR LQKPDTIIQE
YLVPAMKELK GNFEGDEAGR VFHEFASFCD QQLQNPDGLE DFRRIEQIRH RKEKEVMDLE
QMMKSAGGKE RDQLRIHRIK AKQWFELDDN EYQRLKKSRV SFLRQCLENY LLSLRASDMF
KNDVLRCCAL WLDNSESEAA NEAVARYIST VPSRKFAPLM NQLSSRLLDV EDTFQPLLSE
LIFRICVEHP YHGMYQMFSS SKSKVGKDLM SNSRYRAANI LVDRLKNDPK VQSTWITLHN
TNISYVRFAM DKLDDGLKSG SKVALRKSVT GQRLEQDIRR QHIPPATMKI DLRVDCDYSH
VPRIEKYLPE FTVASGVSAP KIVTAIASDG LKYKQLFKGG NDDLRQDSIM EQVFEQVSNL
LRDHRATQQR NLGIRTYKVL PLTANAGIIE FVQNTIPLHD YLMPAHQRHY PKDMKPNACR
KNINDAQPRT LEYRVKIFRQ VTDHFHPVMK FFFMEKFKEP DDWFSKRLAY TRSTAAISML
GHVLGLGDRH GHNILLDEGT GEVVHIDLGV AFEQGRVLPI PEMVPFRLTR DLVDGMGITK
TEGVFRRCCE FTLEALRQES YSIMTILDVL RYDPLYSWSL SPLRIKKMQD TQQAAGGADQ
ASEGGKSKNP KEPSEADRAL TVVAKKLGKT LSVAATVNEL IQQATDERNL AVLYSGWAAY
A
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