ID C1GEV2_PARBD Unreviewed; 863 AA.
AC C1GEV2;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 2.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=CTLH domain-containing protein {ECO:0000259|PROSITE:PS50897};
GN ORFNames=PADG_05788 {ECO:0000313|EMBL:EEH49709.2};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH49709.2, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:EEH49709.2, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:EEH49709.2,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
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DR EMBL; KN275963; EEH49709.2; -; Genomic_DNA.
DR RefSeq; XP_010761214.1; XM_010762912.1.
DR AlphaFoldDB; C1GEV2; -.
DR STRING; 502780.C1GEV2; -.
DR GeneID; 22584655; -.
DR KEGG; pbn:PADG_05788; -.
DR VEuPathDB; FungiDB:PADG_05788; -.
DR eggNOG; KOG0293; Eukaryota.
DR HOGENOM; CLU_000288_57_25_1; -.
DR InParanoid; C1GEV2; -.
DR OMA; RGYNFDN; -.
DR OrthoDB; 5491841at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22838; WD REPEAT PROTEIN 26-RELATED; 1.
DR PANTHER; PTHR22838:SF0; WD REPEAT-CONTAINING PROTEIN 26; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001628};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 401..425
FT /note="CTLH"
FT /evidence="ECO:0000259|PROSITE:PS50897"
FT REPEAT 581..622
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 801..826
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 26..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 863 AA; 94476 MW; 1299F4EF7FBB6AA7 CRC64;
MCAAPPLFGI PPVSIIPGSL LAVTKAQHHH DNKSPSVLLE DPDQPDIDLN RTHPKTVGRL
IEHDKSVIIT APSEEKSSWR VWPAPELSQA GGLSSNFDLA DESPSHTPAP AAPGPSNPSI
VLQSAPTPPI PISSTASDVQ ISHENPPPSL SNNVPPPGLQ SLGSHTGHRE SGELGSHQPN
HRRRRRERTP DQSERAGSRS RNLSPGQRRR RRSVEEHARD INGDDFPPSP KRRRLVDTNM
RSDGGASTSN TNGFSPISNG STTSPLRKSA VASSTNDRSP HSSSNGQSHA NGSGKSPASL
SPTYFGHDRQ EVTRILIQSL HDLGYDEAAS TLSRESGFQL ETPAVAAFRS AVLDGRWTDA
EGILLASYYS DGGGGGTSTI RGTESDILPE HDFLILADGA DKNEMLFRLR QQKFLELLVQ
RDLGTALMVL RQELTPLNHD IAQLHALSRL LMCPADSLRA QAGWNGSVLQ SRQKLLSDLS
KSISPAVMIP DHRLAVLLDH VKENQINQCL YHNTAMPPSL YSDHQCDRSQ FPLRTSLELT
ELTDEVWYLE FSHDGTKLAT AGRENLVIIY DVATFAVIHR LTDHGGSVAY ATWSPDDTKL
ISCSHDYKAR LWDVETGRCI LTIDHHHEPV TSAAWAPDSE SFVTGSLDSQ SQLCLWSVVG
ESLYKWSGNY RVRDCSISPD GSRLVAISTE KSVYVYNFET RVEEYSMTLK LDLTCVNISR
DSRYMLLSTS ECEVQLLGIE TGEVVRQYLG QKQGNFIIRS TFGGAAENFV VSGSEDSKIH
IWHKENCTLV ATLQGHGHGC VNAVSWNPKD PGMFASAGDD HKVRIWTRDP PTCTPVSGKV
RMPSNGAART SALRSTFNRS SNF
//
