ID C1GVQ1_PARBA Unreviewed; 756 AA.
AC C1GVQ1;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 2.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=Nucleoside-triphosphatase ntp-1 {ECO:0000313|EMBL:EEH40273.2};
GN ORFNames=PAAG_02328 {ECO:0000313|EMBL:EEH40273.2};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH40273.2, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH40273.2, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN293996; EEH40273.2; -; Genomic_DNA.
DR RefSeq; XP_015701655.1; XM_015844607.1.
DR AlphaFoldDB; C1GVQ1; -.
DR STRING; 502779.C1GVQ1; -.
DR GeneID; 9098866; -.
DR KEGG; pbl:PAAG_02328; -.
DR VEuPathDB; FungiDB:PAAG_02328; -.
DR eggNOG; KOG1386; Eukaryota.
DR HOGENOM; CLU_010246_3_0_1; -.
DR OMA; WHDALFD; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IEA:UniProt.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF121; NUCLEOSIDE-DIPHOSPHATASE MIG-23; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 553..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 637..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 160
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 197..201
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 756 AA; 82777 MW; 0C20D214493D48ED CRC64;
MLTWRYAVVL DAGSSGTRSY VYRWPDSVKA RKSASAKDLA SLPEIITSEK YTKKIHPGIQ
QSVHGANPST ISGISTFAQN PQDVGLEHLR PLLHHVQEVI PEEDVPDTPI FLLATAGMRL
LPKAQQKSIL NNVCTYIRQT TDFLIPDCNQ HVQVIEGVTE GLYGWIATNY LMGGFDDSRS
HNHGKGHHTY GFLDMGGASA QIAFAPNATE AQKHANDLTL LRLRSVNGRA LEYKVFVMSW
LGFGAQEARS RYVKALLESS VDEMNKGRPD PCLHAGLRMS ADGTILPPEG PVSGVEPYLV
GTGKFDQCLL QTFPLLEKDA PCPDEPCLLH GVHVPAIDFD VNHFIGVSEY WHTTHGIFDM
GDKDDPYNFY DYLQRAKDFC SQPWDEIEAG VRGQRWGGKV SKKTANEICF KASWLINILH
DGIGIPRSSI GEAEVTTGHN NRTQDVVVSG KPDGYLDAFQ AVNKIGATEV SWTLGKAVLY
ASSQVPPLKN GLPVGFGSNV PGGVPDDFQH TGPQLQPLPP TSQPTLPTND TITGTNRQHW
HDTLFDGHSP RRIPGLFLFL AIVAIAIFFL YGRERRNRVY RRFLGRPISR HSSSFHYRRR
SKGLFNSKLS SFFFFSPSPR RSSYIPYERT LEDGMREFEL GPGSSSSDDE ASATYDEDGS
SSVNLLARSK SSTSTSNNIS SVGGGGGGGG NRASVGLGLS LDGNGSLLSS HNVGIMDRNG
LAVRTESRDR QAHLALAPTT NGRRSRATSP VRKSVV
//