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Database: UniProt
Entry: C1GVY4_PARBA
LinkDB: C1GVY4_PARBA
Original site: C1GVY4_PARBA 
ID   C1GVY4_PARBA            Unreviewed;       857 AA.
AC   C1GVY4;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   07-JUN-2017, entry version 36.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=PAAG_02679 {ECO:0000313|EMBL:EEH40703.2};
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis;
OC   Paracoccidioides.
OX   NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH40703.2, ECO:0000313|Proteomes:UP000002059};
RN   [1] {ECO:0000313|EMBL:EEH40703.2, ECO:0000313|Proteomes:UP000002059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A.,
RA   Goldberg J., Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M.,
RA   Grynberg M., Gujja S., Heiman D.I., Henn M.R., Kodira C.D.,
RA   Leon-Narvaez H., Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L.,
RA   Morais F.V., Pereira M., Rodriguez-Brito S., Sakthikumar S.,
RA   Salem-Izacc S.M., Sykes S.M., Teixeira M.M., Vallejo M.C.,
RA   Walter M.E., Yandava C., Young S., Zeng Q., Zucker J., Felipe M.S.,
RA   Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G., Puccia R.,
RA   San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KN293997; EEH40703.2; -; Genomic_DNA.
DR   RefSeq; XP_015701796.1; XM_015844718.1.
DR   STRING; 502779.XP_002795203.1; -.
DR   EnsemblFungi; EEH40703; EEH40703; PAAG_02679.
DR   GeneID; 9098397; -.
DR   KEGG; pbl:PAAG_02679; -.
DR   EuPathDB; FungiDB:PAAG_02679; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002059};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    426    451       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    472    491       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    550    568       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    580    603       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    662       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    760    783       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    789    813       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    135       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   857 AA;  97764 MW;  5E739E0A3325DF61 CRC64;
     MGVPHDTIFR SADMSLTQLY IANEIGREVV SALGELGQVQ FRDLNTDTTA FQRTFTNEIR
     RLDNVERQLR YFHSQMEKAG IPMRPSSEFS NTLAAPMASE IDELADRSES LEQRVASLNE
     SYETLKKREA ELIERRWVLR EAGGFFDRAH GHTDEIRQSF ENDEAPLLRD VEQQHPRGRN
     GDAETQTFSV MNIGFVAGVI PRDRIGSFER ILWRTLRGNL YMNQSEIPDP IINPANNEEI
     HKNVFVIFAH GKEILAKIRK ISESLGADLY SVDENSELRR DQVYDVNTRL ADVGSVLRNT
     KNTLDAELAQ IARSLAAWMI IIKKEKATYH TLNKFSYDQA RKTLIAEAWC PTNSLPLIKT
     TLQDVNDRAG LSVPTIVNQI RTNKTPPTYI KTNKFTEGFQ TIINAYGTSK YGEVNPGLPT
     IVTFPFLFAV MFGDAGHGML MTMVACAMIL FERKLLKTKL DELTSMAFYG RYIMLMMGVF
     SIYTGLIYND IFSKSMEIFP SAWKWPENFK QGETVNAELK GSYRYPFGLD WAWHGTENDL
     LFANSFKMKL SILLGWSHMT YSLCLSYING RHFKKPIEIW GNFVPGMIFF QSIFGYLAFT
     IIYKWVVDWN AHGQSPPGLL NLLIFMFLKP GTVNEQLYRG QATVQVILLL LALVQVPILL
     FLKPFYLRWE HNRARALGYR GLGETARVSA LDEDNEDSHL SGNVRESMAS DAEGIAMITQ
     DLGEEEHETF EFSEAMIHQI IHTIEFCLNC VSHTASYLRL WALSLAHQQL SVVLWTMTIG
     GAFSQETNTM RVILIIVTFF MWFTLTFAIL CVMEGTSAML HSLRLHWVEA MSKHFIGDGV
     PFVPFSFKTL LEEEPVD
//
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