ID C1GX28_PARBA Unreviewed; 429 AA.
AC C1GX28;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Pyridoxal-5'-phosphate-dependent enzyme {ECO:0000313|EMBL:EEH41116.2};
GN ORFNames=PAAG_03402 {ECO:0000313|EMBL:EEH41116.2};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH41116.2, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH41116.2, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the serine/threonine dehydratase family.
CC {ECO:0000256|ARBA:ARBA00010869}.
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DR EMBL; KN293998; EEH41116.2; -; Genomic_DNA.
DR RefSeq; XP_015701931.1; XM_015844957.1.
DR AlphaFoldDB; C1GX28; -.
DR STRING; 502779.C1GX28; -.
DR GeneID; 9098236; -.
DR KEGG; pbl:PAAG_03402; -.
DR VEuPathDB; FungiDB:PAAG_03402; -.
DR eggNOG; KOG1251; Eukaryota.
DR HOGENOM; CLU_021152_4_2_1; -.
DR OMA; LIHPFDH; -.
DR OrthoDB; 2786467at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR CDD; cd01562; Thr-dehyd; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR PANTHER; PTHR43050; SERINE / THREONINE RACEMASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43050:SF1; SERINE RACEMASE; 1.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059}.
FT DOMAIN 125..378
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
SQ SEQUENCE 429 AA; 45526 MW; 5A62F07DEEBB4773 CRC64;
MTDPANWNPL TASNVLSAHA LIKPYVHETP LLTSRALNRI ASTPQSPSAL LGTPFEGQTP
ANPKINFFFK CENFQRIGAF KARGAFHALL RLLQVVGAEE VRRRGVVTHS SGSYAPPRQL
VELIGCKTRN HAQALSLAAS TLHIPAHIVM PSISTRSKIA GTRAHGARIV FSGPTSQERE
AVVASIVRET GAFLIPPYNH PDVVLGQGTV AVEMARQVRE LVGRDGRVSV HWADGDGSAD
ANAANDAEPG TLDAVITPIG GGGLNAGVAT YFSGCRGGAR PLVFGAEPSF QGGDDCRRGL
ERGSRITSVK TLTVADGLRT PVGEVPWEVI SDKGKVEGVY AVSERQIREA MRLVFERVKI
VVEPSAVVGL AVCLFDEGFR RRVEEQCRVS GKRGWDVGVV LSGGNVGLES VGEMFGGSEG
EGRQADGGI
//
