ID C1GY60_PARBA Unreviewed; 2159 AA.
AC C1GY60;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Calcium channel subunit Cch1 {ECO:0000313|EMBL:EEH41451.2};
GN ORFNames=PAAG_03014 {ECO:0000313|EMBL:EEH41451.2};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH41451.2, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH41451.2, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KN293999; EEH41451.2; -; Genomic_DNA.
DR RefSeq; XP_015702024.1; XM_015844818.1.
DR AlphaFoldDB; C1GY60; -.
DR STRING; 502779.C1GY60; -.
DR GeneID; 9097857; -.
DR KEGG; pbl:PAAG_03014; -.
DR VEuPathDB; FungiDB:PAAG_03014; -.
DR eggNOG; KOG2301; Eukaryota.
DR HOGENOM; CLU_000443_0_0_1; -.
DR OMA; TLFIAWN; -.
DR OrthoDB; 1386981at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 5.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 387..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 838..854
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 889..910
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 997..1020
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1223..1249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1261..1286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1306..1331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1352..1379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1477..1498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1557..1577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1589..1607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1619..1639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1645..1663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1675..1699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1775..1794
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1813..1848
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2014..2132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2020..2051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2071..2110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2159 AA; 244325 MW; EA400A870BBF38EF CRC64;
MASPNNNHYD MGNYDTGPPP INQSIPLQDL SRPPDTANPD GTGRRCNKPT SSSGAGGREG
YPVRRLSFIG RTGIGRRYER IAEDSPSPHE RSRIENFQNI SLTPRPRPNS PASHAEEDEP
IDPETSRNFQ EAIGSVGLSF DPLQFSSRSP GQERPYQAHV RDSDDLTRFP YADQQTSNDE
ETYMPPTDTP ENDTTPLTDQ RYLQPMDGAS ISHGQRHDRR SGSVHFVEGA TVAGSHLGDD
LPNLEEGNTR SRSGSRSLQP YRSRSRQISP ATPNSALSRA GSMVRKMSQR VVNISNEPEI
VEQTLRRKSS LKQARLEAPP SLPAMTEYAH DMSNPGLEDG YPPEKRPSLF SKIRDLDAYQ
TEENPLRGNS LGIFSPQSKL RRALLEILIH PATEPIILVL IIVQTVLLAI ESSVYKGKRG
SHWGTPAFDY AFLALFIIYT LEIGARIIVS GLILNPGEYS TLDRSLGLRK ALIAKGKDLL
MPQRQLSTRK PPGPSDPQVS VLRSFTGMQN ASDPSGDAGS LQRFRLARRA FLRHSFTRID
FLAVVSYWIS FVLSNLSFES QHHLYVFRML SCLRILRLLG LTSGTSVIFR SLKKAAPLLV
HVAFLISFFW LLFAIVGVQS FKSSLRRTCV WIDPDGQNNF TLNDAPDKIQ FCGGYHELGT
GAEKPWVTPD GTPGSGPAKG YLCPEGSLCV QGSNPYGGTI SFDNVAHSLQ LVFVVMSSNT
FTDILYYTTD TDYLAAALFF VFGFIVLSLW LVNLLVAVIT SSFQVIREES KRSAFTSEKI
DEREFEDATP RKLRGLKLFY ARTYWVWIAV IGFGLVVQCL RSSTMGPSRA KIIDSTEVVV
TIIMAVEICL RFASDWRNFF KNVRNWVDLS LAIITSIILI SPIRDSPRMY AALSIFQVLR
IYRIVLAFSV TSDLTKIVFK NAVGFLNLII FVFLITFLSS IFAVQLFRGQ MPSDSDAEIT
FFDIYNSFLG MYQILSSENW TSILYSAVQS TYPWDTAWIT AIFLIMWFIL ANFVVLNMFI
AVIQESFDVS EDEKRIQQVK AFLQQKQLSG SSQGNLSLST IFRLGRSSQR YRDPLDHGPA
ALEMLLKDAV VNEFLDEQPR SPPTDTPQVE SPSDHTQHGN AFTNMFNSIT NRIMDREPNP
FYSKLKFSKV YDDSDPTAMA KEVLSASEQR KRAQRQYLQK YPSYNVSLYI FKPTHPLRRF
CQRIVGPGRG SSRIEGVDPY KPVWYTFSAF IYAAIVTMVL IACIATPLYQ RTFLETHKPG
IGNWFVWTDI AFAILFTIEA VIKVIADGFF WTPNAYFRGS WGFIDGIVLI TLWVNVVSAI
FNATGASRVV GAFKALRALR LLNVSDSARE TFHAVIILGG WKVISAAFVS MSFLVPFAIY
GLNLFNGMMR SCNDNDFGYT SLDNCVGEYM STPYAWDVLA PRVVSNPYYS FDNFGESLFI
LFQIVSQEGW TGVLWNAMSI NGVNQQPVPL ASQENGLFFV VFNLLGAVFV LTLFVSVFMR
NYTEQTGVAF LTVEQRSWLE LRKHLRQISP SKRSIDKDSK KLKAWCYRIA IKKHGRWSRF
INGLLLFHLL LLVLEFYPES SWWDRTRDVL FLILTLFYIA NILIRVIGLT WQRFRRSSWD
LYSIISVSGT FFTTVLSVIR YNNIVFARLH KLFLVSIVLL LIPRNNQLDQ LFKTAAASLP
AIGNLLATWF VLFLVYAIAL TQIFGLTKFG GGETGNINFR DVPRALILLF RTSCGEGWNE
IMEDFATMVP PYCTAENHIF QSDCGSAGWA RTLFISWNIV SMYIFVSLFV SLIFESFSYV
YQRSSGLYAI SREEIRRFKQ AWATYDPDGT GYISKEVFPR LLGELSGIFE MRIYDGDFTV
GRILEDCKVH RRESNPAPYV RAVDGIDLDK LQRRISRIPV QQIRRKRARM NTFYEEVLVS
ADPERGISFT SCLMILAHYN VITDSKSLRL EEFLRRRARL QRVEEAVRRS VVIGFFDTLY
WSRKFRRRFE PHDASRLVSV PQFAVPEIYV DDAEHEEQHP CQQQQQSQQQ LQQRQHSPSQ
HSDSSFPSPM LSPDALSRPP GTPPGSGHLR NLPSLDTNIS QGSRNSSSPT RASEWGNRSP
SLSPRQSRIV RGFYSSDPPS PDDIANHRRH DSSVSLQEVV ESLDNSAWGE SIRRSFTLR
//
